Palorid 1 mg (Tablet)

Unit Price: ৳ 14.00 (3 x 10: ৳ 420.00)
Strip Price: ৳ 140.00

Medicine Details

Category Details
Generic Prucalopride succinate
Company One pharma ltd
Also available as
Palorid 2 mg tablet

Indications

  • Symptomatic treatment of chronic constipation in adults

Pharmacology

  • Acts as a selective stimulator of the 5-HT4 receptors
  • Stimulates motility by interacting specifically with 5-HT4 receptors in the GI tract

Dosage & Administration

  • Adults: 2 mg once daily with or without food
  • Older people: Start with 1 mg once daily; if needed the dose can be increased to 2 mg once daily
  • Children: Prucalopride should not be used in children and adolescents younger than 18 years

Interaction

  • Low interaction potential with therapeutic concentrations
  • No significant effects on the pharmacokinetics of warfarin, digoxin, alcohol, paroxetine, or oral contraceptives

Contraindications

  • Hypersensitivity to the active substance or to any of the excipients
  • Renal impairment requiring dialysis

Side Effects

  • Most frequently reported adverse reactions are headache and gastrointestinal symptoms (abdominal pain, nausea, and diarrhea)
  • Majority of adverse events were mild to moderate in intensity

Pregnancy & Lactation

  • Not recommended during pregnancy
  • Women of childbearing potential should use effective contraception during treatment
  • Not recommended during breastfeeding based on animal studies

Precautions & Warnings

  • A dose of 1 mg is recommended in subjects with severe renal impairment
  • Caution in patients with severe hepatic impairment (Child-Pugh class C)
  • Efficacy of oral contraceptives may be reduced in case of severe diarrhea

Use in Special Populations

  • Renal Impairment: The dose for patients with severe renal impairment is 1 mg once daily
  • Hepatic Impairment: Patients with severe hepatic impairment start with 1 mg once daily which may be increased to 2 mg if required

Overdose Effects

  • May result in symptoms like headache, nausea, and diarrhea
  • Treatment is symptomatic and supportive measures

Therapeutic Class

  • Osmotic purgatives

Storage Conditions

  • Store at room temperature, below 30°C
  • Do not remove desiccant
  • Dispense in original bottle

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