Zoben 200 mg/5 ml (Oral Suspension)

10 ml bottle: ৳ 18.00

Medicine Details

Category Details
Generic Albendazole
Company Amico laboratories ltd
Also available as
Zoben 400 mg chewable tablet

Indications

  • Single infestations of hookworm (Ancylostoma, Necator)
  • Mixed infestations of roundworm (Ascaris), threadworm (Enterobius), whipworm (Trichuris), strongyloides, tapeworm, opisthorchi, hydatid

Description

  • Benzimidazole anthelmintic
  • Active against most nematodes and some cestodes
  • Used in the treatment of intestinal nematode infections
  • Used in higher doses for the treatment of hydatid disease
  • Exhibits vermicidal, ovicidal, and larvicidal activity
  • Inhibitory effect on tubulin polymerization

Pharmacology

  • Broad spectrum anthelmintic
  • Exhibits vermicidal, ovicidal, and larvicidal activities
  • Blocks glucose uptake in susceptible helminths
  • Depletes energy level of helminths for survival
  • Binds and inhibits parasite tubulin polymerization
  • Extensively metabolized, probably in the liver
  • Poorly absorbed from the gastrointestinal tract
  • Rapid extensive first-pass metabolism
  • Principal metabolite albendazole sulphoxide has anthelmintic activity
  • Excretion in urine with other metabolites

Dosage & Administration

  • Recommended dose for adults & children over 2 years: 400 mg as a single dose for certain infections
  • Recommended dose for strongyloidiasis or taeniasis: 400 mg daily for 3 consecutive days
  • Recommended dose for hydatid disease: 400 mg twice daily for patients weighing over 60 kg
  • Recommended dose for cystic echinococcosis: 28 days course may be repeated after 14 days without treatment
  • Recommended dose for alveolar echinococcosis: cycles of 28 days of treatment followed by 14 days without treatment may need to continue for months or years
  • Recommended dose for giardiasis: 400 mg once daily for five days
  • Recommended dose for children of 1-2 years: 200 mg as a single dose
  • Not recommended for children under 1 year

Interaction

  • No reported pharmacodynamic or pharmacokinetic interactions

Contraindications

  • Not normally used in neonates
  • Dose reduction may be indicated in children weighing less than 10 kg
  • Should not be given during pregnancy or women thought to be pregnant
  • No evidence to suggest dose alteration in renal, hepatic, or cardiac failure

Side Effects

  • Gastrointestinal disturbances
  • Headache
  • Dizziness
  • Changes in liver enzymes
  • Reversible alopecia (rare)
  • Rash
  • Fever
  • Blood disorders including leucopenia and pancytopenia
  • Allergic shock if cyst leakage
  • Convulsion and meningism in cerebral disease

Pregnancy & Lactation

  • US FDA Pregnancy category: C
  • Avoided in pregnancy and lactation unless potential benefits outweigh possible risks to the fetus

Precautions & Warnings

  • Blood counts and liver function tests before treatment and twice during each cycle
  • Breastfeeding
  • Exclude pregnancy before starting treatment
  • Use in the treatment of Echinococcosis only under constant medical supervision with regular monitoring

Therapeutic Class

  • Anthelmintic

Storage Conditions

  • Keep in a dry place
  • Away from light and heat
  • Keep out of the reach of children

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