Denbac 50 mg (Capsule)
Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00
Medicine Details
Category | Details |
---|---|
Generic | Dantrolene sodium |
Company | Beacon pharmaceuticals plc |
Also available as |
Indications
- Control manifestations of clinical spasticity
- Beneficial for patients with upper motor neuronal disorders
- Beneficial for patients with spinal cord injury, stroke, cerebral palsy, or multiple sclerosis
- Not indicated for skeletal muscle spasm resulting from rheumatic disorders
- Aid in restoring residual function
- Prevent or attenuate signs of malignant hyperthermia
- Use in chronic spasticity
- Use in malignant hyperthermia
Pharmacology
- Relaxation of skeletal muscle
- Affects contractile response of skeletal muscle
- Interferes with release of Ca++ from sarcoplasmic reticulum
Dosage & Administration
- Gradual titration schedule for adults
- Gradual titration schedule for pediatric patients
- Maximum accepted dosage
- Preoperative administration for malignant hyperthermia
- Post-crisis follow-up dosage
Interaction
- Potential drowsiness
- Concomitant administration with CNS depressants
- Hepatotoxicity occurrence in women over 35 years on estrogen therapy
Contraindications
- Active hepatic disease such as hepatitis and cirrhosis
Side Effects
- Drowsiness
- Dizziness
- Weakness
- General malaise
- Fatigue
- Diarrhea
- Transient side effects early in treatment
Pregnancy & Lactation
- Pregnancy category C
- Use during pregnancy if potential benefit justifies potential risk to fetus
- Not to be used in nursing mothers
Precautions & Warnings
- Potential for liver damage in long-term use
- Caution against driving or participating in hazardous occupations
- Caution in concomitant administration of tranquilizing agents
- Possibility of photosensitivity reaction
- Risk of fatal and non-fatal liver disorders
- Baseline liver function studies at the start of therapy
- Liver function studies at appropriate intervals during therapy
- Caution in patients with impaired pulmonary function
- Caution in patients with severely impaired cardiac function
- Caution in patients with a history of previous liver disease or dysfunction
Use in Special Populations
- Long-term safety not established in pediatric patients under 5 years
- Benefit-risk consideration of long-term use in pediatric patients
Therapeutic Class
- Centrally acting Skeletal Muscle Relaxants
Storage Conditions
- Store in a cool & dry place
- Protected from light