Xerova EZ 10 mg+10 mg (Tablet)

Indications

• Reduction of elevated total cholesterol
• Reduction of low density lipoprotein cholesterol (LDL-C)
• Reduction of triglycerides (TG)
• Increase of high-density lipoprotein cholesterol (HDL-C)
• Treatment for homozygous familial hypercholesterolemia (HoFH)
• Adjunct to diet for atherosclerotic vascular disease
• Adjunct to other lipid lowering treatments
• Multifactor intervention for atherosclerotic vascular disease
• Reduction of apolipoprotein B (Apo B)
• Reduction of non-high-density lipoprotein cholesterol (non-HDL-C)
• Therapy for primary hyperlipidemia
• Reduction of elevated total-C and LDL-C in patients with HoFH

Pharmacology

• Lowers plasma cholesterol levels by inhibiting HMG-CoA reductase
• Reduces blood cholesterol by inhibiting absorption in the small intestine
• Increases hepatic LDL receptors to enhance uptake and catabolism of LDL
• Reduces LDL production and number of LDL particles

Dosage & Administration

• Dosage range of 10/10 mg to 80/20 mg daily
• Recommended starting dose of 10/10 mg or 20/10 mg daily
• Administration as a single dose with or without food
• Dosage adjustment based on lipid levels analysis
• Higher dose for patients requiring larger reduction in LDL-C
• Adjusted dosage for patients with homozygous familial hypercholesterolemia
• Contraindicated in patients with active liver disease or unexplained persistent elevations in hepatic transaminase levels
• No dosage adjustment needed in patients with renal impairment

Interaction

• Increased risk of myopathy with concurrent administration of certain drugs
• Coadministration considerations for various medications and health conditions

Contraindications

• Active liver disease
• Hypersensitivity to any component of the preparation

Side Effects

• Rhabdomyolysis
• Myopathy
• Liver enzyme abnormalities
• Myalgia
• Abdominal pain

Pregnancy & Lactation

• Contraindicated in pregnancy
• Lipid-lowering drugs offer no benefit during pregnancy
• Unknown excretion in human milk
• Effect on fetal development

Precautions & Warnings

• Caution with colchicine coadministration
• Temporary withholding or discontinuation in patients with myopathy
• Liver enzyme tests prior to therapy initiation
• Caution with drugs that may decrease levels or activity of endogenous steroid hormones

Use in Special Populations

• Safety and effectiveness not established in pediatric patients
• No dosage adjustment necessary in geriatric patients

Overdose Effects

• No specific treatment recommended
• Symptomatic and supportive measures

Therapeutic Class

• Other lipid regulating drugs

Storage Conditions

• Do not store above 30°C
• Keep in a dry place
• Protect from light
• Keep out of the reach of children

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