Demobet 0.05% (Cream)

Indications

• Psoriasis (excluding widespread plaque psoriasis)
• Recalcitrant dermatoses
• Lichen planus
• Discoid lupus erythematosus
• Other skin conditions which do not respond satisfactorily to less potent steroids

Composition

• Clobetasol Propionate Cream: Each gram cream contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
• Clobetasol Propionate Ointment: Each gram ointment contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
• Clobetasol Propionate Scalp Application: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
• Clobetasol Propionate Shampoo: Each gram shampoo contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
• Clobetasol Propionate Lotion: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
• Clobetasol Propionate Spray: Each gram spray contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)

Pharmacology

• Very potent topical corticosteroid
• Anti-inflammatory, antipruritic and vasoconstrictive properties
• Inhibits late phase allergic reactions
• Decreases density of mast cells
• Reduces cytokine production

Dosage

• Adults, elderly and children over 1 year
• Apply a thin layer of Clobetasol Propionate Cream or Ointment twice daily
• Maximum weekly dose should not exceed 50 gm/week
• Treatment should be limited to 2 consecutive weeks

Administration

• Route of administration: Cutaneous
• Creams suitable for moist or weeping surfaces
• Ointments suitable for dry, lichenified or scaly lesions

Interaction

• Co-administered drugs that can inhibit CYP3A4 may increase systemic exposure

Contraindications

• Rosacea, acne vulgaris and perioral dermatitis
• Hypersensitivity to the preparation
• Not indicated for primarily infected skin lesions caused by fungi or bacteria
• Dermatoses in children under one year of age

Side Effects

• Prolonged use of large amounts can result in systemic absorption
• Local atrophic changes in the skin with prolonged and intensive treatment
• Exacerbation of symptoms may occur

Pregnancy & Lactation

• Limited data from the use in pregnant women
• Caution should be exercised when administered to a nursing woman

Precautions & Warnings

• Long-term continuous therapy should be avoided, especially in infants and children
• Potential atrophic changes after prolonged treatment on the face
• Care needed to ensure the preparation does not enter the eye

Use in Special Populations

• Long-term continuous therapy should be avoided in infants and children under 12 years

Overdose Effects

• Acute overdosage is very unlikely to occur
• Chronic over-dosage or misuse may lead to hypercortisolism

Therapeutic Class

• Other Topical corticosteroids

Storage Conditions

• Keep below 30°C temperature
• Protected from light and moisture
• Keep out of the reach of children

Related Brands

• Dermotil 0.05% (Cream) - euro-pharma-ltd
• Demobet 0.05% (Ointment) - dbl-pharmaceuticals-ltd