Demobet 0.05% (Ointment)

Title and Categories

• Demobet Clobetasol Propionate Cream
• Dermatologicals
• Corticosteroids

Indications

• Psoriasis (excluding widespread plaque psoriasis)
• Recalcitrant dermatoses
• Lichen planus
• Discoid lupus erythematosus
• Other skin conditions not responding to less potent steroids

Composition

• Clobetasol Propionate Cream
• Clobetasol Propionate Ointment
• Clobetasol Propionate Scalp Application
• Clobetasol Propionate Shampoo
• Clobetasol Propionate Lotion
• Clobetasol Propionate Spray

Pharmacology

• Potent topical corticosteroid
• Anti-inflammatory
• Antipruritic
• Vasoconstrictive properties
• Inhibition of late phase allergic reactions
• Decreased mast cell density
• Inhibition of cytokine production
• Metabolism inhibition of arachidonic acid

Dosage

• Application frequency: twice daily
• Super-high potency topical corticosteroid
• Limit treatment to 2 consecutive weeks
• Maximum weekly dose limit: 50 gm/week
• Limit courses for children if possible to five days
• Total scalp application dosage not to exceed 50 ml weekly
• Limit shampoo treatment to 4 consecutive weeks
• Administration route: cutaneous
• Creams suitable for moist or weeping surfaces
• Ointments suitable for dry, lichenified or scaly lesions

Administration

• Route: cutaneous
• Creams suitable for moist or weeping surfaces
• Ointments suitable for dry, lichenified or scaly lesions

Interaction

• CYP3A4 inhibition by co-administered drugs (e.g. ritonavir, itraconazole)

Contraindications

• Rosacea, acne vulgaris, perioral dermatitis
• Hypersensitivity to the preparation
• Not indicated for infected skin lesions caused by fungi or bacteria
• Dermatoses in children under one year of age including dermatitis and napkin eruptions

Side Effects

• Prolonged use may lead to systemic absorption
• Local atrophic changes in the skin (e.g. thinning, striae)
• Possible provocation of pustular form of psoriasis
• Reports of pigmentation changes and hypertrichosis
• Signs of hypersensitivity may occur

Pregnancy & Lactation

• Limited data in pregnant women
• Topical corticosteroids in animals can cause foetal abnormalities
• Caution advised during lactation

Precautions & Warnings

• Avoid long-term continuous therapy, especially in infants and children
• Atrophic changes more likely on the face
• Avoid application to eyelids to prevent eye entry
• Hazardous in psoriasis due to several reasons
• Appropriate anti-microbial therapy for inflammatory lesions

Use in Special Populations

• Avoid long-term therapy in infants and children under 12 years
• Children more susceptible to atrophic changes

Overdose Effects

• Acute overdosage unlikely
• Chronic over-dosage may lead to hypercortisolism features

Therapeutic Class

• Topical corticosteroids

Storage Conditions

• Keep below 30°C
• Protect from light and moisture
• Do not freeze
• Keep out of the reach of children

Related Brands

• Dermotil 0.05% (Cream) - euro-pharma-ltd