C-Fenac Plus (75 mg+20 mg)/2 ml (IM Injection)

Indications

• Relieves pain and inflammation in arthritic conditions
• Relieves pain in musculoskeletal disorders
• Treats trauma-induced pain
• Relieves pain in renal colic

Pharmacology

• Potent nonsteroidal antiinflammatory drug (NSAID)
• Has analgesic and antipyretic properties
• Inhibits prostaglandin synthesis
• Has uricosuric effects
• Lidocaine acts as a local anaesthetic

Dosage & Administration

• Adult dosage: one ampoule once daily by intramuscular injection
• Renal colic dosage: one ampoule once daily intramuscularly, may repeat after 30 minutes if necessary
• Recommended dosage for children and elderly patients

Interaction

• May increase plasma concentrations of Lithium and Digoxin
• Reports of increased risk of haemorrhage with anticoagulant therapy
• Can be given together with oral antidiabetic agents without influencing their clinical effect
• Cases of nephrotoxicity with concomitant use of Cyclosporin
• Potential of serious toxicity when used with Methotrexate
• Caution needed when considering concomitant therapy with quinolones
• Increased frequency of unwanted effects with other NSAIDs and steroids
• Inhibition of diuretic activity with various NSAIDs

Contraindications

• Hypersensitivity to Diclofenac or local anaesthetics
• Active or suspected peptic ulcer or gastrointestinal bleeding
• Incidence of hypersensitive reactions to specific excipients

Side Effects

• Mild and transient gastrointestinal discomfort, nausea, diarrhea, and bleeding
• Rare instances of injection site disorder, abscesses, and local necrosis
• Adverse effects due to Lidocaine mainly involve the CNS and are dose related

Pregnancy & Lactation

• Not recommended unless compelling reasons exist
• Lowest effective dosage should be used
• Not recommended during the last trimester of pregnancy
• Small quantities may be detected in breast milk with no expected undesirable effects on the infant

Precautions & Warnings

• Close observation for patients with severe hepatic, cardiac, or renal insufficiency or the elderly
• Renal function monitoring for patients using NSAIDs
• Discontinuation if abnormal liver function tests persist or worsen
• Monitoring of all patients receiving long term treatment with NSAIDs

Therapeutic Class

• Drugs for Osteoarthritis
• Drugs used for Rheumatoid Arthritis
• Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

• Store at temperature not exceeding 30°C in a dry place
• Protected from light

Related Brands

• Relnac Plus (75 mg+20 mg)/2 ml (IM Injection) - albion-laboratories-limited