Tinicev 400 mg (Tablet)
Unit Price: ৳ 350.00 (3 x 10: ৳ 10,500.00)
Strip Price: ৳ 3,500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Imatinib mesylate |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Treatment for adult and pediatric patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+CML) in various disease phases
- Treatment for adult patients with specific types of leukemia and myeloproliferative diseases
- Treatment for patients with specific types of gastrointestinal stromal tumors
- Adjuvant treatment following complete gross resection of Kit (CD117) positive gastrointestinal stromal tumors
Pharmacology
- Small molecule protein-tyrosine kinase inhibitor
- Potent inhibitor of Bcr-Abl tyrosine kinase and several receptor tyrosine kinases
- Actions on Kit, DDR1, DDR2, CSF-1R, PDGFR-alpha, and PDGFR-beta receptors
- Details on absorption, distribution, metabolism, and excretion
Dosage & Administration
- Specific daily dosage for different conditions and patient groups
- Instructions on administration with meal and water
- Guidance for patients with hepatic impairment
- Option to dissolve in water or apple juice for patients with swallowing difficulty
Interaction
- Effects of CYP3A4 inducers and inhibitors on imatinib exposure
- Interactions with drugs metabolized by CYP3A4 and CYP2D6
- Caution for concomitant use with specific medications
Side Effects
- Description of serious adverse reactions including fluid retention, hematologic toxicity, and hepatotoxicity
- Warnings about potential cardiac, gastrointestinal, dermatologic, and endocrine adverse effects
- Adverse effects related to driving and use of machinery
Pregnancy & Lactation
- Guidance for effective contraception during treatment and after stopping treatment
- Limited data on use during pregnancy and distribution in human milk
- Recommendation against breastfeeding during treatment and after stopping treatment
- Advisory on fertility and consultation with physician
Precautions & Warnings
- Management of edema, cytopenias, and severe fluid retention
- Monitoring and treatment for cardiac, hepatic, and gastrointestinal issues
- Caution for pregnant women and growth monitoring in children
Overdose Effects
- Reported events at different dose ranges in adult and pediatric populations
- General management and symptomatic treatment for overdose
Therapeutic Class
- Targeted Cancer Therapy
- Tyrosine Kinase Inhibitor
Storage Conditions
- Storage temperature and environmental requirements