Rith 500 mg (Tablet)
Unit Price: ৳ 38.00 (7 x 2: ৳ 532.00)
Strip Price: ৳ 76.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clarithromycin |
| Company | Chemist laboratories ltd |
| Also available as |
Indications
- Treatment of acute bacterial exacerbation of chronic bronchitis in adults
- Treatment of acute maxillary sinusitis
- Treatment of community-acquired pneumonia
- Treatment of pharyngitis or tonsillitis
- Treatment of uncomplicated skin and skin structure infections
- Treatment of acute otitis media in pediatric patients
- Treatment and prophylaxis of disseminated mycobacterial infections
- Treatment of Helicobacter pylori infection and duodenal ulcer disease in adults
Mode of Action
- Inhibits microsomal protein synthesis in susceptible organisms
- Binds to the donor site on the 50S subunit of the bacterial ribosome
- Prevents translocation to the donor site
- Active against most Gram-positive bacteria and Chlamydia
- Some activity against Gram-negative bacteria and Mycoplasmas
- Twice the activity of Erythromycin against H. influenzae
- More acid-stable than Erythromycin
- Better tolerated due to acid-stability
Dosage & Administration
- Dosage varies based on condition and patient age
- Dosage for adults with different infections
- Combination dosing regimens for H. pylori infection
- Recommended dosages for pediatric patients
- Administration for renal and hepatic impairment
Interaction
- Contraindicated with specific medications
- Not recommended with antiarrhythmics drugs
- Caution with drug interactions
Contraindications
- Hypersensitivity to macrolide antibacterial drugs
- History of cholestatic jaundice or hepatic dysfunction
- Known hypersensitivity to clarithromycin or erythromycin
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Stomatitis
- Glossitis
- Headache
- Allergic reactions
- Taste perversion
- Central nervous system side effects
- Anxiety
- Dizziness
- Insomnia
- Hallucination
Pregnancy & Lactation
- Use in neonates and children in appropriate doses
- Avoid breastfeeding until treatment is completed
- Not recommended during pregnancy
Precautions & Warnings
- Discontinue if severe acute hypersensitivity reactions occur
- Avoid in patients with known QT prolongation
- Discontinue if signs and symptoms of hepatitis occur
- Increased risk of all-cause mortality in patients with coronary artery disease
- Evaluation for Clostridium difficile associated diarrhea
- Exacerbation of myasthenia gravis reported
Use in Special Populations
- Safety and effectiveness in pediatric patients
- Use in children and adolescents
Overdose Effects
- Ingestion of large amounts can cause gastro-intestinal symptoms
- Altered mental status
- Paranoid behaviour
- Hypokalemia
- Hypoxemia
- Prompt elimination of unabsorbed drug and supportive measures
Therapeutic Class
- Macrolides
Storage Conditions
- Store in a cool and dry place
- Protected from light & moisture
- Reconstituted suspension must be used within specified time frames
- Keep out of reach of children