Vicozol 200 mg (Tablet)

Unit Price: ৳ 100.00 (1 x 4: ৳ 400.00)
Strip Price: ৳ 400.00

Medicine Details

Category Details
Generic Voriconazole
Company Chemist laboratories ltd

Indications

  • Treatment of invasive aspergillosis
  • Treatment of candidemia and disseminated candidiasis
  • Treatment of esophageal candidiasis
  • Treatment of serious infections caused by specific fungal species
  • Use in patients intolerant of or refractory to other therapy

Pharmacology

  • Mechanism of action involving inhibition of ergosterol synthesis
  • Binding and inhibition of CYP450-dependent 14-alpha sterol demethylase
  • Resultant depletion of ergosterol in fungal cell membrane

Dosage & Administration

  • Oral administration with specific dosing regimens based on body weight
  • Oral administration before or after a meal
  • Injection dosage for invasive aspergillosis, candidemia, Scedosporiosis, and Fusariosis

Interaction

  • Need for dosage adjustments and monitoring with CYP3A4, CYP2C9, and CYP2C19 inhibitors and inducers
  • Potential increase in concentrations and activity of drugs that are CYP3A4, CYP2C9, and CYP2C19 substrates
  • Increased maintenance dosage with co-administration of specific drugs

Contraindications

  • Known hypersensitivity to Voriconazole or any components of the drug
  • Co-administration contraindications with specific medications

Side Effects

  • Common side effects such as abdominal pain, anemia, blurred vision, headache, chest pain, nausea, and diarrhea

Pregnancy & Lactation

  • Lack of adequate and well-controlled studies in pregnant women
  • Use during pregnancy only if potential benefit justifies potential risk to the fetus

Precautions & Warnings

  • Careful assessment of benefit-risk balance for long-term exposure exceeding 180 days
  • Reported association with squamous cell carcinoma of the skin with long-term treatment

Use in Special Populations

  • Unestablished efficacy in children under 12 years of age

Overdose Effects

  • No available data on overdose effects

Therapeutic Class

  • Belongs to the therapeutic class of other antifungal preparations

Reconstitution

  • Instructions for reconstituting the suspension and storage thereafter

Storage Conditions

  • Necessary storage conditions including temperature and protection from light

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