Vicozol 200 mg (Tablet)
Unit Price: ৳ 100.00 (1 x 4: ৳ 400.00)
Strip Price: ৳ 400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Voriconazole |
| Company | Chemist laboratories ltd |
Indications
- Treatment of invasive aspergillosis
- Treatment of candidemia and disseminated candidiasis
- Treatment of esophageal candidiasis
- Treatment of serious infections caused by specific fungal species
- Use in patients intolerant of or refractory to other therapy
Pharmacology
- Mechanism of action involving inhibition of ergosterol synthesis
- Binding and inhibition of CYP450-dependent 14-alpha sterol demethylase
- Resultant depletion of ergosterol in fungal cell membrane
Dosage & Administration
- Oral administration with specific dosing regimens based on body weight
- Oral administration before or after a meal
- Injection dosage for invasive aspergillosis, candidemia, Scedosporiosis, and Fusariosis
Interaction
- Need for dosage adjustments and monitoring with CYP3A4, CYP2C9, and CYP2C19 inhibitors and inducers
- Potential increase in concentrations and activity of drugs that are CYP3A4, CYP2C9, and CYP2C19 substrates
- Increased maintenance dosage with co-administration of specific drugs
Contraindications
- Known hypersensitivity to Voriconazole or any components of the drug
- Co-administration contraindications with specific medications
Side Effects
- Common side effects such as abdominal pain, anemia, blurred vision, headache, chest pain, nausea, and diarrhea
Pregnancy & Lactation
- Lack of adequate and well-controlled studies in pregnant women
- Use during pregnancy only if potential benefit justifies potential risk to the fetus
Precautions & Warnings
- Careful assessment of benefit-risk balance for long-term exposure exceeding 180 days
- Reported association with squamous cell carcinoma of the skin with long-term treatment
Use in Special Populations
- Unestablished efficacy in children under 12 years of age
Overdose Effects
- No available data on overdose effects
Therapeutic Class
- Belongs to the therapeutic class of other antifungal preparations
Reconstitution
- Instructions for reconstituting the suspension and storage thereafter
Storage Conditions
- Necessary storage conditions including temperature and protection from light