VomitOF 8 mg/4 ml (IM/IV Injection)
4 ml ampoule: ৳ 25.00 (2 x 5: ৳ 250.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Chemist laboratories ltd |
| Also available as |
Indications
- Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Description
- Orally dissolving film designed to be applied on top of the tongue
- Dissolves within 20 seconds and then is swallowed with saliva
- Does not require water to aid dissolution or swallowing
- Active ingredient: VomitOF base, the racemic form of VomitOF
Pharmacology
- Potent, highly selective 5HT3 receptor-antagonist
- Mode of action in control of nausea and vomiting not fully known
- Blocks initiation of vomiting reflex by activating vagal afferents
- Antagonism of 5HT3 receptors on neurons located in peripheral and central nervous system
Dosage
- Different dosage for adults, pediatric patients, radiotherapy, and postoperative nausea and vomiting
- Variety of oral tablet and orodispersible tablet doses
- Injection option for different age groups and conditions
Administration
- Step-by-step instructions for administration of oral soluble film
Interaction
- Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
- Inducers or inhibitors of these enzymes may change the clearance and half-life of VomitOF
Contraindications
- Hypersensitivity to the drug or any of its components
- Concomitant use of apomorphine
Side Effects
- Frequently reported adverse events: headache, constipation, diarrhea
- Mild or moderate nature of adverse events
- Rash, sensation of flushing or warmth, hiccups, liver enzyme abnormalities
- Rare cases of anaphylaxis, bronchospasm, tachycardia, chest pain, hypokalemia, shortness of breath
- No evidence of extrapyramidal reactions
Pregnancy & Lactation
- No evidence of impaired fertility or harm to the fetus due to Ondansetron in animal studies
- Cautious administration in pregnant and nursing women
Precautions & Warnings
- Hypersensitivity reactions reported in patients with hypersensitivity to other selective 5-HT3 receptor antagonists
- Not a drug that stimulates gastric or intestinal peristalsis
- Should not be used instead of nasogastric suction
- Use in patients following abdominal surgery or in patients with chemotherapy-induced nausea and vomiting may mask a progressive ileus and/or gastric distension
Use in Special Populations
- Same dosage recommendation for patients with impaired renal function
- Single maximal daily dose recommendation for patients with severe hepatic impairment
- Little information available about dosage in pediatric patients 4 years of age or younger
- No dosage adjustment needed in patients over the age of 65
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Store at temperature not exceeding 30°C in a dry place
- Protect from light and moisture