Promox 500 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Amoxicillin trihydrate |
| Company | Chemist laboratories ltd |
| Also available as |
Indications
- Ear, nose and throat infections
- Lower respiratory tract infections
- Skin and soft tissue infections
- Genito-urinary tract infections
- Venereal disease
- Dental abscess
Pharmacology
Effective against a wide range of Gram-positive and Gram-negative bacteria. Acts through inhibition of biosynthesis of cell wall. Stable in the presence of gastric acid and rapidly absorbed after oral administration.
Dosage
- Adult:
- 250 mg three times daily
- Increasing up to 500 mg three times daily for severe infections
- Children:
- 125 mg three times daily
- Increasing up to 250 mg three times daily for severe infections
- Severe or recurrent purulent respiratory infection: 3 gm every 12 hours
- Otitis media:
- Recommended dose: 1 g three times daily for adults
- 40 mg/kg body weight daily in 3 divided doses for children (max. 3 g daily)
- Pneumonia: Recommended dose: 500-1000 mg three times daily
- Dental abscess: Recommended dose: 3 gm, repeated after 10-12 hours
- Urinary tract infections: Recommended dose: 3 gm, repeated after 10-12 hours
- Gonorrhoea: Single dose of 2-3 gm with Probenecid 1 gm is recommended (Probenecid is contraindicated in children under 2 years)
- In renal impairment: May be necessary to reduce the total daily dosage
Administration
Reconstituted suspension can be administered by adding the required amount of suspension to milk, fruit juice, or water. These preparations should then be taken immediately.
Interaction
Concurrent use of Promox and Probenecid may result in increased and prolonged blood levels of Promox. Promox may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.
Contraindications
Amoxicillin is contraindicated in penicillin hypersensitive patients.
Side Effects
- Diarrhoea
- Indigestion
- Occasional rash
- Pseudo-membranous colitis rarely reported
Pregnancy & Lactation
US FDA pregnancy category of Amoxicillin is B. Caution should be exercised when Amoxicillin is administered to a lactating mother.
Precautions & Warnings
The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur, Promox should be discontinued and appropriate therapy should be instituted.
Therapeutic Class
Broad spectrum penicillins
Reconstitution
- Amoxycillin 500 mg Injection:
- Intramuscular: Add 2.5 ml water for injection to Amoxycillin 500 mg injection vial
- Intravenous: Dissolve Amoxycillin 500 mg injection in 10 ml water for injection
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.