Mabrix 10 mg/ml (IV Infusion)

100 mg vial: ৳ 13,000.00

Medicine Details

Category Details
Generic Rituximab
Company Aci limited

Indications

  • Non-Hodgkin’s Lymphoma (NHL) treatment
  • Chronic Lymphocytic Leukemia (CLL) treatment
  • Rheumatoid Arthritis (RA) treatment
  • Granulomatosis with Polyangiitis (GPA) treatment
  • Pemphigus Vulgaris (PV) treatment

Pharmacology

  • Monoclonal IgG1 kappa antibody
  • CD20 antigen targeting
  • Approximate molecular weight: 145 kD
  • Binding affinity for CD20 antigen: 8.0 nM

Dosage & Administration

  • Intravenous infusion only
  • Different rates for first and subsequent infusions
  • Recommended doses for different indications
  • Premedication necessary before each infusion
  • Dosage based on patient's condition and age

Interaction

  • No formal drug interaction studies performed
  • No alteration of systemic exposure to specific drugs

Contraindications

  • Known hypersensitivity to Rituximab or its components

Side Effects

  • Reactivation of hepatitis B virus
  • Infusion-related reactions
  • Mucocutaneous reactions
  • Progressive Multifocal Leukoencephalopathy (PML)
  • Tumor Lysis Syndrome (TLS)
  • Serious infections

Pregnancy & Lactation

  • Potential fetal harm
  • Adverse developmental outcomes in infants
  • Adverse outcomes regardless of maternal health or medication use
  • Limited data on presence in human milk
  • Excretion in low concentrations in human breast milk

Precautions & Warnings

  • Severe infusion-related reactions
  • Severe mucocutaneous reactions
  • Progressive Multifocal Leukoencephalopathy (PML)
  • Tumor Lysis Syndrome (TLS)
  • Serious infections

Therapeutic Class

  • Cytotoxic immunosuppressants

Storage Conditions

  • Refrigeration at 2°C-8°C
  • Protection from light
  • Keep out of reach of children

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