Probis 1.25 mg (Tablet)
Unit Price: ৳ 3.50 (3 x 10: ৳ 105.00)
Strip Price: ৳ 35.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Bisoprolol hemifumarate |
| Company | Aci limited |
| Also available as |
Title
- Probis 1.25 mg Tablet
Categories
- Medicine
- Pharmaceutical
- Healthcare
Indications
- Hypertension
- Angina
- Moderate to severe heart failure
Mode of Action
- Selective ß1 blocker
- Heart rate reduction
- Cardiac output reduction
- Arterial hypertension reduction
- Lipid metabolism impact
- Therapeutic reliability
Pharmacokinetic Properties
- High absorption rate
- Small first-pass effect
- Absolute bioavailability
- Extensive distribution
- Renal elimination of metabolites
- Low inter and intra-individual variability of plasma concentration profiles
- Single daily dose
Dosage & Administration
- Adult dosage: 5 mg once daily (with/without diuretic)
- Potential dosage increment to 10 mg or 20 mg once daily
- Dose titration interval: 2 weeks
- Limited data for safety and effectiveness in children
- Initial daily dose of 5 mg for patients with renal or hepatic impairment
- No need for drug replacement in dialysis patients
- No usual dose adjustment for elderly
Interaction
- Not to be combined with other β-blocking agents
- Close monitoring with catecholamine-depleting drugs
- Careful use with centrally active antihypertensive agents
- Caution with myocardial depressants or inhibitors of A-V conduction
- Risk of severe hypotension, bradycardia, and cardiac failure with combined use of β-blockers and calcium channel blockers
Contraindications
- Cardiogenic shock
- Overt heart failure
- Second or third degree A-V block
- Right ventricular failure secondary to pulmonary hypertension
- Sinus bradycardia
Side Effects
- Fatigue
- Dizziness
- Headache
- Disturbances of the gut (nausea, vomiting, diarrhea, constipation, abdominal pain)
- Cold or numb extremities
- Muscle weakness or cramps
- Breathing difficulties (bronchospasm)
Pregnancy & Lactation
- Not teratogenic in rats at certain doses
- Fetotoxic and maternotoxic at higher doses
- No studies in pregnant women
- Potential risk to the fetus
- Detection in lactating rats
- Unknown excretion in human milk
- Suggestion to stop nursing if essential use is considered
Precautions & Warnings
- Use caution in adjusting the dose for patients with impaired renal or hepatic function
- Increased reactivity to allergens in patients with severe anaphylactic reaction history
- Reduced responsiveness to usual doses of epinephrine in allergic reactions
Therapeutic Class
- Anti adrenergic agent (Beta blockers)
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Dry place away from light and heat
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C18H31NO4
- Link to Chemical Structure Image
Commonly Asked Questions
- Usage information
- Potential side effects
- Safety concerns for specific health conditions
- Instructions for intake and storage
- Quick tips for safe usage