Dopatic 10 mg (Tablet)
Unit Price: ৳ 3.00 (6 x 10: ৳ 180.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Dbl pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of dyspeptic symptom complex
- Relief from acute nausea and vomiting
- Management of symptoms in Parkinson's disease
- Facilitating radiological studies
Pharmacology
- Dopamine antagonist
- Blocks dopamine receptors in Chemoreceptor Trigger Zone (CTZ) and stomach
- Restores normal motility and tone of upper gastrointestinal tract
- Facilitates gastric emptying
- Enhances antral and duodenal peristalsis
- Regulates contraction of the pylorus
- Increases esophageal peristalsis
- Enhances lower esophageal sphincter pressure
Dosage & Administration
- To be taken 15-30 minutes before meals
- Usual recommended oral dose for adults: 10-20 mg every 6-8 hours daily
- Maximum daily dose for adults: 80 mg
- Different dosage for children based on body weight
- Rectal administration in suppositories for adults and children
- Max treatment period for acute nausea and vomiting: 12 weeks
Interaction
- Antagonism with anticholinergic drugs
- Lowered oral bioavailability with antacids and antisecretory drugs
- Metabolism through CYP3A4 pathway
- Possible inhibition of CYP3A4 due to other drugs
- No potentiation of action with neuroleptics
- Suppression of unwanted peripheral effects of dopaminergic agonists
Contraindications
- Hypersensitivity to the drug
- Neonates
- Dangerous gastrointestinal stimulation conditions
- Prolactin releasing pituitary tumor (prolactinoma)
Side Effects
- Rare occurrence of transient intestinal cramps
- Rare extrapyramidal phenomena especially in children
- Potential increase in plasma prolactin level
- Possible allergic reactions such as rash and urticaria
Pregnancy & Lactation
- Limited usage during first trimester if justified by therapeutic benefit
- No evidence of increased risk of malformations in humans
- Excretion in breast milk with lower concentrations than plasma
- Nursing not recommended unless benefits outweigh risks
Precautions & Warnings
- Caution in children due to risk of extra-pyramidal reactions
- Caution in patients with hepatic impairment
Use in Special Populations
- Caution in infants due to immature blood-brain barrier
- Caution in patients with liver and kidney disorders
- Dosing adjustment in patients with severe renal insufficiency
Overdose Effects
- Symptoms may include drowsiness, disorientation
- Use of activated charcoal and close patient observation recommended
- Anticholinergic or antihistamines may help control extrapyramidal reactions
Therapeutic Class
- Motility Stimulants
- Dopamine antagonist
- Prokinetic drugs
Storage Conditions
- Store below 30°C
- Protected from light & moisture
- Keep out of children's reach
Chemical Structure
- Molecular Formula: C22H24ClN5O2
Common Questions
- Relieves nausea, vomiting, and indigestion
- Should be taken before meals as per doctor's prescription
- May cause dizziness and sleepiness
- Avoid alcohol consumption
- Inform doctor about persistent side effects
- Do not exceed 7 days of usage without consulting doctor