Doxobron 100 mg/5 ml (Syrup)

100 ml bottle: ৳ 100.00

Medicine Details

Category Details
Generic Doxophylline
Company Team pharmaceuticals ltd
Also available as
Doxobron 200 mg tablet Doxobron 400 mg tablet

Indications

  • Bronchial asthma
  • Bronchospasm
  • Chronic obstructive pulmonary disease (COPD)
  • Pulmonary disease with spastic bronchial component

Pharmacology

Doxophylline selectively inhibits phosphodiesterase 4, relaxes bronchial smooth muscle, inhibits platelet activating factor (PAF) and generation of leukotriene production

Dosage & Administration

  • Elderly: 200 mg tablet two or three times daily
  • Adults: 400 mg tablet two or three times daily
  • Children:
    • >12 years: 10 ml syrup or 200 mg tablet two or three times daily
    • 6-12 years: 6-9 mg/kg body weight two times daily

Interaction

  • Interactions: Doxobron should not be administered with other xanthine preparations, limit consumption of caffeine-containing beverages and food, caution in administering with ephedrine or other sympathomimetic drugs
  • Drugs that may affect:
    • Erythromycin
    • TAO
    • Lincomycin
    • Clindamycin
    • Allopurinol
    • Cimetidine
    • Influenza vaccine
    • Propanolol
    • Phenytoin
    • Other anticonvulsants
    • Cigarette smoking

Contraindications

Known hypersensitivity to the drug or other xanthine derivatives, acute myocardial infarction, hypotension, lactation

Side Effects

  • Nausea
  • Vomiting
  • Epigastric pain
  • Headache
  • Irritability
  • Insomnia
  • Tachycardia
  • Extrasystoles
  • Tachypnea
  • Hyperglycemia
  • Albuminuria

Pregnancy & Lactation

  • Use during pregnancy should be evaluated carefully
  • Contraindicated during lactation
  • No sufficient clinical evidence about effects during pregnancy
  • No interference with ability to drive and use machines

Precautions & Warnings

  • Factors affecting hepatic clearance: Age, congestive cardiac decompensation, chronic obstructive pulmonary disease, severe liver disease, concomitant infections
  • Patients to use with caution:
    • Cardiac disease
    • Hypertension
    • Elderly
    • Severe hypoxemia
    • Hyperthyroidism
    • Chronic corpulmonale
    • Congestive heart failure
    • Liver disease
    • Peptic ulcer
    • Renal impairment

Overdose Effects

Severe cardiac arrhythmias, tonic-clonic seizure, requires discontinuation of treatment, symptomatic treatment of cardiovascular collapse

Therapeutic Class

Bronchodilator, Methyl xanthine derivatives

Storage Conditions

Keep in a dry place away from light and heat, keep out of the reach of children, use only on prescription of specialist physician

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