Evania-M 5 mg+500 mg (Tablet)

Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Empagliflozin metformin hydrochloride
Company Healthcare pharmaceuticals ltd

Indications

  • Treatment of adults with type 2 diabetes mellitus
  • Adjunct to diet and exercise
  • Uncontrolled diabetes with Metformin
  • Combination therapy with other diabetes medications
  • Treatment of patients already on Empagliflozin and Metformin separately

Pharmacology

  • Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
  • Reduces renal reabsorption of glucose
  • Lowers renal threshold for glucose
  • Increases urinary glucose excretion
  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerability
  • Twice daily with meals
  • Gradual dose escalation to reduce gastrointestinal side effects
  • Maximum recommended daily dose of Metformin Hydrochloride 2000 mg and Empagliflozin 25 mg
  • Extended-release formulations available
  • Dosage adjustment for renal impaired patients
  • Safety and effectiveness in pediatric patients not established

Interaction

  • Increased urine volume and frequency of voids with diuretics
  • Increased risk of hypoglycemia with insulin or insulin secretagogues
  • Monitoring glycemic control with urine glucose tests not recommended
  • Drugs that reduce Metformin clearance may increase accumulation
  • Risk of lactic acidosis with carbonic anhydrase inhibitors
  • Potential for altered glycemic control with certain drugs
  • Alcohol can potentiate the effect of Metformin on lactate metabolism

Contraindications

  • Hypersensitivity to Empagliflozin and Metformin
  • Acute metabolic acidosis
  • Severe renal failure (GFR <30 ml/min)
  • Conditions altering renal function
  • Tissue hypoxia-related diseases
  • Hepatic impairment, acute alcohol intoxication, alcoholism

Side Effects

  • Urinary tract infection and female genital mycotic infections
  • Diarrhea, nausea/vomiting, flatulence, abdominal discomfort, indigestion, asthenia, headache
  • Hypoglycemia, gastrointestinal symptoms, vaginal moniliasis, vulvovaginitis, balanitis, urinary tract infection, thirst, taste disturbance, pruritus, rash, increased urination, increased serum lipids, volume depletion, urticaria, dysuria, increased blood creatinine/GFR, increased haematocrit, diabetic ketoacidosis

Pregnancy & Lactation

  • Potential risk to fetus especially in the second and third trimesters
  • Not recommended during breastfeeding

Precautions & Warnings

  • Risk of lactic acidosis
  • Assessment and correction of volume status
  • Monitoring for hypotension
  • Assessment for signs of metabolic acidosis and ketoacidosis
  • Consideration for temporary discontinuation in reduced oral intake or fluid losses
  • Increased risk for urinary tract infections and genital mycotic infections
  • Risk of hypoglycemia, Vitamin B12 deficiency, increased LDL-C, and lack of conclusive evidence for macrovascular risk reduction

Overdose Effects

  • No toxicity seen with single or multiple doses of Empagliflozin within specified limits
  • Lactic acidosis is a potential emergency for Metformin overdose
  • Treatment should be initiated based on the patient's clinical status
  • Haemodialysis as the most effective method for lactate and Metformin removal

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light and moisture
  • Keep out of the reach of children

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