Nilotin 200 mg (Capsule)
Unit Price: ৳ 800.00 (7 x 4: ৳ 22,400.00)
Strip Price: ৳ 3,200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Nilotinib |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of Philadelphia chromosome positive chronic myeloid leukemia
- Treatment of newly diagnosed adult patients
- Treatment of chronic phase and accelerated phase
- Clinical benefit determination
- Improvement in disease-related symptoms
Pharmacology
- Inhibition of BCR-ABL oncogene
- Inhibition of tyrosine kinase activity
- High affinity to ATP-binding site
- Inhibition of TEL-platelet-derived growth factor receptor-beta
- Inhibition of FIP1-like-1-PDGFRalpha
Dosage & Administration
- Recommended dose for newly diagnosed Ph+ CML-CP
- Recommended dose for resistant or intolerant Ph+ CML-CP and CML-AP
- Twice daily oral administration
- Timing of administration in relation to food consumption
- Dose adjustment for toxicities and drug interactions
Interaction
- Reduced solubility and bioavailability with drugs that inhibit gastric acid secretion
Contraindications
- Contraindications for patients with specific medical conditions
- Incompatibility with specific classes of drugs
Side Effects
- Various side effects including rash, hepatotoxicity, headache, GI disturbances, alopecia, myalgia, oedema, insomnia, dizziness, anxiety, myelosuppression, thrombotic disorders, arrhythmias, and more
Pregnancy & Lactation
- Pregnancy Category D
- Requirement for effective contraception
- Inadvisability of breastfeeding
- Lack of data for use in pediatrics
- Lower starting dose recommendation for patients with hepatic impairment
Precautions & Warnings
- Need for precautions in patients with specific medical history
- Relevance of maintaining adequate hydration and correcting electrolyte imbalances
Overdose Effects
- Symptoms of overdose including neutropenia, vomiting, and drowsiness
- Management through monitoring and supportive treatment
Therapeutic Class
- Belonging to the class of Targeted Cancer Therapy
Storage Conditions
- Storage recommendations in a cool and dry place, away from light and children