Novea 20 mg+20 mg (Tablet (Extended Release))

Title

• Doxylamine Succinate & Pyridoxine Hydrochloride Tablets

Categories

• Medicine
• Pregnancy care
• Anti-emetic drugs

Description

• Tablets for the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management.
• Combination of antihistamine and vitamin B6 analog to prevent nausea and vomiting.

Indications

• Treatment of nausea and vomiting of pregnancy

Mode of Action

• Antihistamine that blocks Histamine (H1) receptor
• Decreases the action of histamine at the H1 receptor
• Inhibits both vestibular system & Muscarinic receptor
• Vitamin B6 analog with antiemetic properties

Dosage & Administration

• Initial dose of one tablet orally at bedtime
• Increase to one tablet in the morning and one tablet at bedtime if symptoms persist
• Maximum recommended dose of two tablets per day
• Take on an empty stomach with a glass of water
• Swallow tablets whole
• Do not crush, chew, or split the tablets
• Take daily and not on an as needed basis

Interaction

• Contraindicated with monoamine oxidase inhibitors (MAOIs)
• Not recommended with alcohol and other CNS depressants

Contraindications

• Known hypersensitivity to the ingredients
• Contraindicated with MAO inhibitors

Side Effects

• Somnolence
• Accidents resulting from combined use with CNS depressants

Pregnancy & Lactation

• Pregnancy category A
• Excreted into breast milk
• Caution while breastfeeding

Precautions & Warnings

• May cause somnolence
• Avoid engagement in activities like driving or operating heavy machinery
• Not recommended with concurrent use of CNS depressants
• Use with caution in women with asthma, increased intraocular pressure, narrow angle glaucoma, peptic ulcer, or urinary bladder-neck obstruction

Overdose Effects

• Extended-release formulation
• Signs and symptoms of intoxication may not be apparent immediately
• Symptoms of overdose include restlessness, dry mouth, dilated pupils, sleepiness, vertigo, mental confusion, tachycardia
• Anticholinergic effects at toxic doses can include seizures, rhabdomyolysis, and acute renal failure
• Treatment includes gastric lavage, activated charcoal, whole bowel irrigation, and symptomatic treatment

Therapeutic Class

• Anti-emetic drugs

Storage Conditions

• Store at below 30°C
• Dry place protected from light
• Keep out of reach of children

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