Toposide 100 mg/5 ml (IV Infusion)

Therapeutic class

• Cytotoxic Chemotherapy

Indications

• Management of Small Cell Lung Cancer
• First-line treatment in patients with small cell lung cancer

Pharmacology

• Pharmacotherapeutic classification: podophyllotoxin derivatives
• Inhibits cell cycle progression at a premitotic phase
• Does not interfere with the synthesis of nucleic acids
• Biphasic process of disposition on intravenous administration

Dosage & Administration

• Dose ranges from 35 mg/m^2/day to 50 mg/m^2/day
• Initial dose modification based on measured creatinine clearance
• Subsequent dosing based on patient tolerance and clinical effect

Interaction

• High-dose cyclosporine a has led to an 80% increase in Toposide exposure
• Laboratory tests: periodic complete blood counts should be done

Contraindications

• Hypersensitivity to Etoposide or any component of the formulation

Side Effects

• Myelosuppression
• Granulocyte nadirs occurring 7 to 14 days after drug administration
• Nausea and vomiting
• Transient hypotension following rapid intravenous administration
• Anaphylactic-like reactions
• Reversible alopecia

Pregnancy & Lactation

• Pregnancy category D
• Etoposide found in human milk
• Patient should not breastfeed while receiving Etoposide

Precautions & Warnings

• Frequent observation for myelosuppression
• Dose limiting bone marrow suppression
• Platelet count, hemoglobin, white blood cell count, and differential should be obtained at the start of therapy and prior to each subsequent cycle
• Physicians should be aware of the possible occurrence of an anaphylactic reaction
• Toposide should be given only by slow intravenous infusion
• Physician must evaluate the need and usefulness of the drug against the risk of adverse reactions
• Patients with low serum albumin may be at an increased risk for Toposide associated toxicities

Storage Conditions

• Must be stored under refrigeration 2°-8°C
• Capsules are stable for 24 months under refrigeration
• Protect from light
• Proper handling and disposal of anticancer drugs should be considered

Related Brands

• Etopor 100 mg/5 ml (IV Infusion) - eskayef-pharmaceuticals-ltd