Nafinex 2% (Cream)

Indications

• Treatment of interdigital tinea pedis
• Treatment of tinea cruris
• Treatment of tinea corporis
• Caused by Trichophyton rubrum

Description

• Synthetic antifungal agent
• Allylamine derivative
• Broad spectrum activity
• Fungicidal activity against various organisms
• Fungistatic activity against Candida species

Pharmacology

• Inhibition of squalene 2,3-epoxidase
• Interference with sterol biosynthesis
• Decreased amounts of sterols
• Accumulation of squalene in the cells

Dosage & Administration

• Topical use only
• Not for ophthalmic, oral, or intravaginal use
• Once-daily application
• 2 weeks treatment duration

Side Effects

• Common adverse reaction: pruritus

Pregnancy & Lactation

• Pregnancy Category B
• No adequate and well-controlled studies in pregnant women
• Use during pregnancy only if benefit justifies risk
• Unknown excretion in human milk

Precautions & Warnings

• Discontinue if redness or irritation develops

Use in Special Populations

• Established safety and effectiveness in age group 12-17
• Safety and effectiveness not established in pediatric patients <12 years
• Limited studies in subjects aged 65 and over

Therapeutic Class

• Topical Antifungal preparations

Storage Conditions

• Store at 25°C
• Excursions permitted to 15-30°C

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