Solu-Medrol 125 mg/vial (IM/IV Injection)
125 mg vial: ৳ 768.28
Medicine Details
| Category | Details |
|---|---|
| Generic | Methylprednisolone sodium succinate |
| Company | Pfizer |
| Also available as |
Indications
- Endocrine disorder
- Rheumatic disorder
- Collagen disease
- Dermatological disease
- Allergic states
- Ophthalmic disease
- Gastrointestinal disease
- Respiratory disease
- Hematologic disorder
- Neoplastic disease
- Edematous state
- Tuberculous meningitis
- Trichinosis
Pharmacology
- Naturally occurring glucocorticoid
- Salt-retaining properties
- Potent anti-inflammatory effects
- Excretion within 12 hours
- Influence on various metabolic and functional capacities
- Suppressive effect on the immune response
Dosage & Administration
- IM or IV administration
- Preparation of solution for reconstitution
- Administration over several minutes
- Recommended high dose
- Continuation until condition stabilization
- Gradual decrease or discontinuation of dosage
- Initial dosage for pediatric patients
- Treatment of acute exacerbations of multiple sclerosis
Interaction
- Aminoglutethimide
- Amphotericin B injection and potassium-depleting agents
- Macrolide antibiotics
- Anticholinesterases
- Anticoagulants, oral
- Antidiabetics
- Antitubercular drugs
- Cholestyramine
- Cyclosporine
- Digitalis glycosides
- Estrogens, including oral contraceptives
- Hepatic Enzyme Inhibitors
- Ketoconazole
- Nonsteroidal anti-inflammatory agents (NSAIDs)
- Skin tests
- Vaccines
Contraindications
- Systemic fungal infections
- Known hypersensitivity to the product and its constituents
- Intrathecal administration
- Idiopathic thrombocytopenic purpura
Side Effects
- Fluid and Electrolyte Disturbances
- Musculoskeletal effects
- Gastrointestinal effects
- Dermatologic effects
- Neurological effects
- Endocrine effects
- Ophthalmic effects
- Others
- Additional adverse reactions related to parenteral corticosteroid therapy
Pregnancy & Lactation
- Teratogenic effects shown in many species
- No adequate and well-controlled studies in pregnant women
- Potential risk to the fetus
- Corticosteroids appearing in human milk
- Decision on nursing continuation based on the importance of the drug to the mother
Precautions & Warnings
- Sensitivity to heat
- Use of lowest possible dose
- Risk/benefit decision for dose and duration of treatment
- Gradual reduction in dosage
- Complications dependent on dose and duration of treatment
Use in Special Populations
- Adverse effects in pediatric patients
- Decrease in growth velocity
- Nursing considerations
- Geriatric considerations
Overdose Effects
- Supportive and symptomatic therapy
- Reduction of dosage for chronic overdose
- Introduction of alternate day treatment
Therapeutic Class
- Glucocorticoids
Reconstitution
- Removal of protective plastic flip-of seal
- Cleansing of stopper with a suitable germicide
- Aseptic addition of Water for Injection BP
- Agitation to effect solution
- Withdrawal of dose
Storage Conditions
- Protection from light
- Controlled room temperature storage
- Use of solution within 48 hours after mixing