Enbrel 50 mg/ml (SC Injection)

1 ml pre-filled syringe: ৳ 29,020.00 (4's pack: ৳ 116,080.00)

Medicine Details

Category Details
Generic Etanercept
Company Pfizer

Product Title

  • Enbrel

Categories

  • Medicine
  • Immunosuppressant

Dosage

  • 50 mg Etanercept per week administered either once weekly or 25 mg Etanercept twice weekly for Rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis
  • 50 mg syringe once weekly or 25 mg twice weekly for plaque psoriasis
  • 0.4mg/kg twice weekly for Juvenile idiopathic arthritis
  • 0.8mg/kg once weekly for Pediatric plaque psoriasis

Indications

  • Reducing signs and symptoms in adults with Rheumatoid Arthritis (RA)
  • Inducing major clinical response in adults with RA
  • Inhibiting the progression of structural damage in adults with RA
  • Improving physical function in adults with RA
  • Treatment of polyarticular-course juvenile idiopathic arthritis (JIA) in children and adolescents
  • Reducing signs and symptoms in adults with Psoriatic Arthritis (PsA)
  • Improving physical function in adults with PsA
  • Reducing signs and symptoms in adults with Ankylosing Spondylitis (AS)
  • Treatment of adult patients with chronic moderate to severe plaque psoriasis (PsO)
  • Treatment of chronic severe plaque psoriasis in children and adolescents

Pharmacology

  • Etanercept is a tumor necrosis factor (TNF) blocker
  • Contains the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1
  • Blocks the interaction of TNF with cell surface TNF receptors
  • Involvement in normal inflammatory and immune responses

Administration

  • Subcutaneous injections in the thigh, abdomen or upper arm
  • Injection site rotation
  • Allowing the pre-filled syringe to reach room temperature before injection
  • Activating needle guard before disposal

Contraindications

  • Hypersensitivity to etanercept or any component of the formulation
  • Sepsis or risk of sepsis
  • Serious active infections, including chronic or localized infection

Side Effects

  • Infections
  • Injection site reactions
  • Allergic reactions
  • Fever
  • Antibodies directed against normal tissue
  • Serious infections
  • Low blood platelet count
  • Skin cancer
  • Localized swelling of the skin
  • Hives
  • Eye inflammation
  • Psoriasis
  • Rash
  • Inflammation or scarring of the lungs
  • Inflammation of the blood vessels affecting multiple organs

Pregnancy & Lactation

  • Not established safe use during pregnancy
  • Not established safe use during lactation
  • Excretion in human milk

Precautions & Warnings

  • Allergic reactions
  • Infections
  • Tuberculosis
  • Hepatitis-B
  • Blood disorders
  • Nervous system and eye disorders
  • Congestive heart failure
  • Cancer
  • Chickenpox
  • Alcohol abuse
  • Anti-diabetic medicine

Overdose Effects

  • Maximum tolerated dose not established in humans
  • No known antidote

Therapeutic Class

  • Immunosuppressant

Storage Conditions

  • Refrigeration at 2-8°C
  • Avoid freezing and shaking
  • Keep away from light
  • Keep out of reach of children

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