Klabex 125 mg/5 ml (Powder for Suspension)

Indications

• Acute bacterial exacerbation of chronic bronchitis in adults
• Acute maxillary sinusitis
• Community-acquired pneumonia
• Pharyngitis or tonsillitis
• Uncomplicated skin and skin structure infections
• Acute otitis media in pediatric patients
• Treatment and prophylaxis of disseminated mycobacterial infections
• Helicobacter pylori infection and duodenal ulcer disease in adults

Pharmacology

• Inhibits microsomal protein synthesis
• Binds to the donor site on the 50S subunit of the bacterial ribosome
• Active against most Gram-positive bacteria and Chlamydia
• More acid-stable than Erythromycin
• Twice the activity of Erythromycin against H. influenzae

Dosage & Administration

• Adult dosages for different indications
• Combination dosing regimens for H. pylori infection
• Recommended daily dosage for children
• Administration in renal and hepatic impairment

Interaction

• Contraindicated with specific medications such as HMG-CoA reductase inhibitors and antipsychotics

Contraindications

• Known hypersensitivity to clarithromycin or macrolide antibacterial drugs
• History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin

Side Effects

• Nausea
• Vomiting
• Diarrhoea
• Abdominal pain
• Stomatitis
• Glossitis
• Headache
• Allergic reactions
• Taste perversion
• Transient central nervous system side effects

Pregnancy & Lactation

• Use in neonates and children in appropriate doses
• Caution with breast milk from mothers receiving Clarithromycin

Precautions & Warnings

• Discontinue in case of severe acute hypersensitivity reactions
• Avoid in patients with known QT prolongation or receiving specific drugs
• Discontinue if signs and symptoms of hepatitis occur
• Increased risk of all-cause mortality in patients with coronary artery disease

Use in Special Populations

• Safety and effectiveness in pediatric patients 6 months and older
• Safety in pediatric patients 20 months and older with advanced HIV infection
• Safety not established in MAC patients under the age of 20 months

Overdose Effects

• Gastro-intestinal symptoms in large amounts
• Altered mental status and paranoid behavior in extreme cases
• Prompt elimination of unabsorbed drug and supportive measures for treatment

Therapeutic Class

• Macrolides

Storage Conditions

• Store in a cool and dry place
• Protected from light & moisture
• Reconstituted suspension must be used within specified timeframes
• Keep out of reach of children

Related Brands

• Clarinaaf 125 mg/5 ml (Powder for Suspension) - naafco-pharma-ltd