Ajwa 10 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Atorvastatin calcium |
| Company | Desh pharmaceuticals ltd |
ProductTitle
- Ajwa 10 mg Tablet
TherapeuticClass
- Other Anti-anginal & Anti-ischaemic drugs
- Statins
Indications
- Adjunct to diet to reduce elevated total cholesterol
- Reduce LDL cholesterol in familial hypercholesterolaemia
- Treatment of hypertriglyceridaemia
Pharmacology
- Selective inhibitor of HMG-CoA reductase
- Lowers plasma cholesterol and lipoprotein levels
- Increases hepatic LDL receptors for enhanced uptake
DosageAdministration
- Adults: 10-80 mg once daily
- Child (10-18 years): 10-20 mg once daily
- Adjusted according to response
- Starting dose of 10 or 20 mg once daily
- Can be administered with or without food
Interaction
- Increased risk of myopathy with cyclosporine, fibric acid derivatives, erythromycin
- Altered plasma concentrations with antacid, colestipol, oral contraceptives
Contraindications
- Hypersensitivity to any component
- Active liver disease
- History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors
SideEffects
- Constipation
- Flatulence
- Dyspepsia
- Abdominal pain
- Headache
- Rash
- Myalgia
PregnancyLactation
- Contraindicated during pregnancy
- Not known if excreted in human milk
- Maternal treatment may reduce fetal levels of mevalonate
- Not recommended during breastfeeding
PrecautionsWarnings
- Liver function tests should be performed before initiation of treatment
- Discontinue therapy if markedly elevated CPK levels occur
- Use with caution in patients with history of liver disease
UsesInSpecialPopulations
- Higher plasma concentrations in geriatric patients
- No clinically significant difference between men and women
- No influence on plasma concentrations in renal insufficiency
OverdoseEffects
- Specific treatment not available
- Symptomatic and supportive measures should be instituted
- Liver function tests and serum CK levels should be monitored
StorageConditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
CompoundSummary
- Molecular Formula: C33H35FN2O5
CommonlyAskedQuestions
- What is Ajwa 10 mg Tablet?
- How should I take Ajwa 10 mg Tablet?
- What are the uses of Ajwa 10 mg Tablet?
- Side Effects of Ajwa 10 mg Tablet
- Instructions for storage and disposal Ajwa 10 mg Tablet
- Is Ajwa 10 mg Tablet used for lowering cholesterol?
- Will taking Ajwa 10 mg Tablet increase my risk of diabetes?
- For how long do I need to take Ajwa 10 mg Tablet?
- Does Ajwa 10 mg Tablet cause weight loss?
- Can I stop taking Ajwa 10 mg Tablet?
- Does Ajwa 10 mg Tablet cause memory loss?
- Does Ajwa 10 mg Tablet make you tired?
- Can Ajwa 10 mg Tablet be prescribed to children?
- Is Ajwa 10 mg Tablet a blood thinner?
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Absorption
Rapidly absorbed after oral administration; maximum plasma concentrations occur within 1 to 2 hours
Distribution
Mean volume of distribution is approximately 381 liters; 98% bound to plasma proteins
Metabolism
Extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products
Excretion
Primary elimination in bile following hepatic and/or extra-hepatic metabolism; mean plasma elimination half-life approximately 14 hours
Antacid
Plasma concentrations of atorvastatin decreased approximately 35% when coadministered with antacid suspension
Colestipol
Plasma concentrations of atorvastatin decreased approximately 25% when coadministered with colestipol
Digoxin
Steady-state plasma digoxin concentrations increased by approximately 20% with coadministration of atorvastatin and digoxin
Erythromycin
Plasma concentrations of atorvastatin increased approximately 40% with coadministration of atorvastatin and erythromycin
OralContraceptives
Coadministration with atorvastatin increased AUC values for norethindrone and ethinyl estradiol by approximately 30% and 20% respectively
Warfarin
No clinically significant effect on prothrombin time when administered to patients receiving chronic warfarin treatment
PreventionOfCardiovascularEvents
Adjunct to diet to reduce cardiac ischaemic events in patients with asymptomatic or mild to moderate symptomatic coronary artery disease
ChemicalStructure
Molecular Formula: C33H35FN2O5