D-Fozin M 5 mg+500 mg (Tablet)
Unit Price: ৳ 18.00 (3 x 10: ৳ 540.00)
Strip Price: ৳ 180.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin metformin hydrochloride |
| Company | Desh pharmaceuticals ltd |
Indications
- Treatment of type 2 diabetes mellitus in adults
- Adjunct to diet and exercise
- Combination therapy with Metformin
- Combination therapy with Empagliflozin
- Switching treatment from separate Empagliflozin and Metformin tablets
Pharmacology
- Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
- Reduces renal reabsorption of glucose
- Lowers renal threshold for glucose
- Increases urinary glucose excretion
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerability
- Take twice daily with meals
- Gradual dose escalation to reduce gastrointestinal side effects
- Maximum recommended daily doses
- Extended-release formulations available
Interaction
- Co-administration with diuretics
- Co-administration with insulin or insulin secretagogues
- Disadvantages of monitoring glycemic control with urine glucose tests
- Drugs that reduce Metformin clearance
- Effect of carbonic anhydrase inhibitors
- Effect of drugs on glycemic control
- Effect of alcohol
Contraindications
- Hypersensitivity to Empagliflozin and Metformin
- Acute metabolic acidosis
- Diabetic pre-coma
- Severe renal failure
- Conditions altering renal function
- Hepatic impairment
- Acute alcohol intoxication
Side Effects
- Urinary tract infection
- Female genital mycotic infections
- Diarrhea
- Nausea/vomiting
- Flatulence
- Abdominal discomfort
- Indigestion
- Asthenia
- Headache
- Hypoglycemia
- Vaginal moniliasis
- Urinary tract infection
- Thirst
- Taste disturbance
- Pruritus
- Rash
- Increased urination
- Increased serum lipids
- Volume depletion
- Urticaria
- Dysuria
- Increased blood creatinine
- Ketoacidosis
Pregnancy & Lactation
- Potential risk to fetus
- Not recommended when breastfeeding
Precautions & Warnings
- Lactic acidosis
- Hypotension
- Ketoacidosis
- Acute kidney injury & impaired renal function
- Risk of urinary tract infections
- Hypoglycemia
- Vitamin B12 deficiency
- Increased LDL-C
- Macrovascular outcomes
Overdose Effects
- No toxicity with high single doses of Empagliflozin
- No hypoglycemia with high Metformin doses
- Lactic acidosis as a medical emergency
- Haemodialysis for Metformin removal
Therapeutic Class
- Oral hypoglycemic preparations
Storage Conditions
- Below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children
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