D-Lina M 2.5 mg+500 mg (Tablet)

Unit Price: ৳ 11.50 (3 x 10: ৳ 345.00)
Strip Price: ৳ 115.00

Medicine Details

Category Details
Generic Linagliptin metformin hydrochloride
Company Desh pharmaceuticals ltd
Also available as
D lina m 25 mg tablet

Indications

  • Adjunct to diet and exercise
  • Improves glycemic control
  • Type 2 diabetes mellitus

Pharmacology

  • Inhibitor of DPP-4 enzyme
  • Increases active incretin hormones
  • Stimulates insulin release
  • Decreases glucagon secretion
  • Oral antihyperglycemic drug
  • Lowers plasma glucose
  • Decreases hepatic glucose production
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerability
  • Maximum recommended dose of 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily with meals
  • Dose escalation should be gradual
  • Immediate release and extended release tablet options
  • Starting dose recommendations for different patient groups

Interaction

  • Cationic drugs interaction
  • Carbonic Anhydrase Inhibitors interaction
  • Inducers of P-glycoprotein and CYP3A4 Enzymes interaction
  • Drugs affecting glycemic control interaction

Contraindications

  • Contraindicated in renal impairment
  • Contraindicated in acute or chronic metabolic acidosis
  • Contraindicated in hypersensitivity to Linagliptin or Metformin Hydrochloride

Side Effects

  • Common side effects: nasopharyngitis and diarrhea
  • Increased risk of hypoglycemia

Pregnancy & Lactation

  • Use during pregnancy only if clearly needed
  • Caution during lactation

Precautions & Warnings

  • Discontinue in case of lactic acidosis
  • Discontinue in case of suspected pancreatitis
  • Temporary discontinuation for certain medical procedures
  • Monitoring of Vitamin B12 levels
  • Symptoms of lactic acidosis and pancreatitis
  • Instructions for alcohol, other medicines, counseling, travel, and emergencies
  • Caution for hypoglycemia

Overdose Effects

  • Supportive measures for overdose
  • Low likelihood of Linagliptin removal by dialysis
  • Metformin Hydrochloride is dialyzable
  • No dose-related clinical adverse reactions for Linagliptin overdose
  • Hypoglycemia reported in Metformin overdose cases
  • Lactic acidosis reported in Metformin overdose cases

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Cool and dry storage below 30°C
  • Protection from light and moisture
  • Keep out of the reach of children

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