D-Lina M 2.5 mg+850 mg (Tablet)
Unit Price: ৳ 14.00 (3 x 10: ৳ 420.00)
Strip Price: ৳ 140.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Linagliptin metformin hydrochloride |
| Company | Desh pharmaceuticals ltd |
| Also available as |
Therapeutic Class
- Combination Oral hypoglycemic preparations
Indications
- Adjunct to diet and exercise
- Improving glycemic control
- Adults with type 2 diabetes mellitus
Pharmacology
- Inhibitor of DPP-4
- Increases concentrations of incretin hormones
- Stimulates insulin release from pancreatic beta cells
- Decreases glucagon secretion from pancreatic alpha cells
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerability
- Maximum recommended doses for immediate and extended release tablets
- Gradual dose escalation to reduce gastrointestinal side effects
- Recommended starting doses for different patient groups
- Instructions for switching from individual components to combination tablet
Interaction
- Potential interaction with cationic drugs
- Potential for competition for renal tubular transport systems
- Possible metabolic acidosis with carbonic anhydrase inhibitors
- Effect of P-glycoprotein and CYP3A4 enzyme inducers on Linagliptin
- Drugs affecting glycemic control and their impact
Contraindications
- Contraindicated in renal impairment
- Contraindicated in acute or chronic metabolic acidosis
- Contraindicated in hypersensitivity to Linagliptin or Metformin Hydrochloride
Side Effects
- Most common: nasopharyngitis and diarrhea
- Increased risk of hypoglycemia with sulfonylureas
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Caution in administration to lactating mothers
Precautions & Warnings
- Discontinuation and supportive therapy in case of lactic acidosis
- Postmarketing reports of acute pancreatitis
- Temporary discontinuation in certain medical procedures
- Monitoring of Vitamin B12 levels
- Symptoms and precautions for lactic acidosis
- Instructions for alcohol, other medicines, counseling, travel, and emergencies
- Warnings about hypoglycemia
Overdose Effects
- Supportive measures in case of overdose
- Removal of unabsorbed material from the gastrointestinal tract
- Clinical monitoring and supportive treatment
- Dialyzability of Metformin Hydrochloride
- Clinical adverse drug reactions with Linagliptin overdose
- Outcome of Metformin Hydrochloride overdose
Storage Conditions
- Cool & dry place (below 30°C)
- Protected from light & moisture
- Keep out of the reach of children