Esomo-Fast 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Esomeprazole
Company Desh pharmaceuticals ltd
Also available as
Esomo fast 40 mg tablet Esomo fast 20 mg capsule Esomo fast 40 mg capsule

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease in combination with amoxicillin and clarithromycin
  • Zollinger-Ellison Syndrome
  • Acid-related Dyspepsia
  • Treatment of duodenal and gastric ulcers

Pharmacology

  • Proton pump inhibitor
  • Specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • Better acid control than racemic proton pump inhibitors
  • Enteric-coated pellet formulation of esomeprazole magnesium
  • Peak plasma levels occur at approximately 1.5 hours after oral administration
  • Metabolized in the liver by the CYP enzyme system
  • Plasma elimination half-life is approximately 1–1.5 hours
  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • 97% bound to plasma proteins
  • Apparent volume of distribution at steady state is approximately 16 L

Dosage

  • Oral dosage form for various conditions and durations
  • IV Injection or IV infusion for different patient age groups
  • Different doses for Zollinger-Ellison Syndrome and acid-related dyspepsia
  • Specific dosage for Helicobacter pylori eradication

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral suspension administration guidelines
  • IV Injection preparation and administration

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • No clinically relevant interactions with drugs metabolized by CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
  • Potential interference with the absorption of drugs where gastric pH is an important determinant of bioavailability
  • No clinically significant interactions with certain drugs

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies have revealed no teratogenic effects
  • Excretion of esomeprazole in milk has not been studied
  • Breastfeeding should be discontinued if the use of esomeprazole is considered essential

Precautions & Warnings

  • Symptomatic response to therapy with Esomo-Fast does not preclude the presence of gastric malignancy
  • Specific administration instructions for patients having difficulty swallowing capsules
  • Antacids may be used while taking Esomo-Fast

Use in Special Populations

  • Safety and effectiveness in paediatric patients have not been established
  • No overall differences in safety and efficacy between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency

Overdose Effects

  • Lethal dose to rats at 103 times the human dose on a body surface area basis
  • Signs of acute toxicity include reduced motor activity, changes in respiratory frequency, tremor, ataxia, and intermittent clonic convulsions
  • No specific antidote known
  • Treatment should be symptomatic and supportive

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Common Questions about Esomo-Fast 20 mg Tablet

  • Description of Esomo-Fast 20 mg Tablet and its uses
  • List of potential side effects of Esomo-Fast 20 mg Tablet
  • Considerations for pregnant or breastfeeding individuals
  • Onset of action for Esomo-Fast 20 mg Tablet

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