Esomo-Fast 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Esomeprazole
Company Desh pharmaceuticals ltd
Also available as
Esomo fast 40 mg tablet Esomo fast 20 mg tablet Esomo fast 40 mg capsule

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Treatment of Zollinger-Ellison Syndrome
  • Treatment of acid-related Dyspepsia
  • Treatment of Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • First single optical isomer of proton pump inhibitor
  • Better acid control than racemic proton pump inhibitors
  • Absorption after oral administration
  • Peak plasma levels occur at approximately 1.5 hours
  • Distribution - 97% bound to plasma proteins
  • Metabolism by cytochrome P450 (CYP) enzyme system
  • Plasma elimination half-life of approximately 1-1.5 hours

Dosage

  • Oral dosage form for healing erosive esophagitis, symptomatic GERD
  • Oral dosage form for Helicobacter Pylori eradication, Zollinger-Ellison Syndrome, Acid-related Dyspepsia, Duodenal & Gastric ulcers
  • IV Injection or IV infusion for GERD with Erosive Esophagitis, Risk reduction of rebleeding of Gastric or Duodenal Ulcers
  • Different dosages for pediatric and adult patients

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension should be taken after mixing with water
  • IV Injection solution for injection is prepared by adding 0.9% Sodium Chloride

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • No clinically relevant interactions with drugs metabolized by CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
  • Potential interference with CYP2C19, the major metabolizing enzyme
  • Co-administration with clarithromycin and amoxicillin increases plasma levels

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects observed in animal studies
  • Excretion in milk not studied
  • Breast-feeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Tablet or capsule should be swallowed at least one hour before meals
  • Usage in patients with difficulty swallowing capsules

Use in Special Populations

  • Safety and effectiveness in paediatric patients have not been established
  • No overall differences in safety and efficacy in geriatric patients
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • No alteration in pharmacokinetics in patients with renal impairment

Overdose Effects

  • Lethal to rats at high doses
  • Symptoms include reduced motor activity, respiratory changes, ataxia, and convulsions
  • No specific antidote known

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image

Common Questions about Esomo-Fast 20 mg Capsule

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