Pregafast 50 mg (Capsule)

Unit Price: ৳ 11.50 (3 x 10: ৳ 345.00)
Strip Price: ৳ 115.00

Medicine Details

Category Details
Generic Pregabalin
Company Desh pharmaceuticals ltd
Also available as
Pregafast 75 mg capsule

Categories and Usage

  • Indicated for neuropathic pain associated with diabetic peripheral neuropathy (DPN)
  • Indicated for postherpetic neuralgia (PHN)
  • Adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older
  • Indicated for fibromyalgia
  • Indicated for neuropathic pain associated with spinal cord injury

Pharmacology

  • Structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
  • Binds with high affinity to the alpha2-delta site in central nervous system tissues
  • Mechanism of action not fully elucidated

Dosage

  • Maximum recommended dose for DPN: 100 mg three times a day
  • Maximum recommended dose for PHN: 75 to 150 mg two times a day or 50 to 100 mg three times a day
  • Recommended dose for fibromyalgia: 300 to 450 mg/day
  • Recommended dose range for neuropathic pain associated with spinal cord injury: 150 to 600 mg/day

Administration

  • Oral route of administration
  • Can be taken with or without food
  • Pregabalin CR tablet should be administered after an evening meal
  • Swallowed whole and should not be split, crushed or chewed

Drug Interaction

  • Unlikely to be involved in significant pharmacokinetic drug interactions

Contraindications

  • Contraindicated in patients with known hypersensitivity to Pregabalin or any of its components

Side Effects

  • Most common side effects in adults: dizziness, somnolence, dry mouth, edema, blurred vision, weight gain
  • Most common side effects in pediatric patients for partial onset seizures: increased weight, increased appetite

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Pregnant women should be advised of potential risk to a fetus
  • Small amounts detected in the milk of lactating women
  • Breastfeeding not recommended due to potential risk of tumorigenicity

Precautions & Warnings

  • Angioedema and hypersensitivity reactions may occur
  • Increase in risk of suicidal thoughts or behavior
  • Respiratory depression may occur when used with concomitant CNS depressants
  • May cause dizziness, somnolence, and impair ability to drive or operate machinery
  • Increased seizure frequency or adverse reactions may occur if rapidly discontinued
  • May cause peripheral edema

Use in Special Populations

  • Safety and effectiveness in pediatric patients not established for certain indications

Overdose Effects

  • Symptoms include reduced consciousness, depression/anxiety, seizures, and heart block
  • No specific antidote available

Therapeutic Class

  • Adjunct anti-epileptic drugs
  • Primary anti-epileptic drugs

Storage Conditions

  • Keep in a cool & dry place (below 30°C)
  • Protected from light & moisture
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C8H17NO2

Commonly Asked Questions

  • Pregafast 50 mg Capsule is an anticonvulsant and is considered to be the first-line of treatment for neurotic pain, shingles, seizures, and fibromyalgia
  • It should be taken till the time improvement in health conditions is seen
  • Dosage should be followed as prescribed by the doctor
  • Should be taken after food in the prescribed dosage
  • Storage instructions: should be kept in a cool dry place and in its original packaging, out of reach of children and pets
  • Does not work in the same way for each disease
  • Duration of use depends on the condition; consult the doctor before discontinuing
  • Can be used with Diazepam
  • May cause weight gain due to increased hunger
  • Quick Tips: should be taken as per dose and duration prescribed, may cause sleepiness and blurring or loss of vision, inform the doctor about any unusual changes in mood or behavior, and not to be stopped suddenly without consulting the doctor

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