Pregafast 75 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Pregabalin |
| Company | Desh pharmaceuticals ltd |
| Also available as |
Indications
- Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
- Postherpetic neuralgia (PHN)
- Adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older
- Fibromyalgia
- Neuropathic pain associated with spinal cord injury
Pharmacology
Pregabalin is a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). It binds with high affinity to the alpha2-delta site in central nervous system tissues, contributing to its anti-nociceptive and antiseizure effects.
Dosage
- Maximum recommended dose of Pregabalin for diabetic peripheral neuropathy is 100 mg three times a day
- For postherpetic neuralgia, the recommended dose ranges from 75 to 300 mg/day based on efficacy and tolerability
- For fibromyalgia, the recommended dose is 300 to 450 mg/day
- For neuropathic pain associated with spinal cord injury, the recommended dose range is 150 to 600 mg/day
Administration
- Route of administration: Oral route, may be taken with or without food
- Pregabalin CR tablet administration: After an evening meal, should be swallowed whole and not split, crushed or chewed
Interaction
- Drug interaction with medication: Unlikely to be involved in significant pharmacokinetic drug interactions
- Drug interaction with food and others: Not applicable
Contraindications
Contraindicated in patients with known hypersensitivity to Pregabalin or any of its components
Side Effects
Common side effects include dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, and difficulty with concentration/attention
Pregnancy & Lactation
No adequate and well-controlled studies with pregabalin in pregnant women, small amounts detected in lactating women's milk, breastfeeding not recommended
Precautions & Warnings
- Angioedema can occur and may be associated with life-threatening respiratory compromise
- Discontinue immediately in cases of hypersensitivity reactions and certain adverse effects
- Increase the risk of suicidal thoughts or behavior
- Respiratory depression may occur when used with concomitant CNS depressants
Use in Special Populations
- Use in children and adolescents: Safety and effectiveness not established for various conditions
Overdose Effects
Signs and symptoms include reduced consciousness, depression/anxiety, confusional state, agitation, restlessness, seizures, and heart block. No specific antidote.
Therapeutic Class
Adjunct anti-epileptic drugs, Primary anti-epileptic drugs
Storage Conditions
Keep in a cool & dry place (below 30°C), protected from light & moisture. Keep out of the reach of children.
Chemical Structure
- Molecular Formula: C8H17NO2
- Chemical Structure Image: https://medex.com.bd/storage/res/g-res-919-pregabalin-chemical-structure-dKjKzfuVRrNkwNMBalNK.svg
Common Questions about Pregafast 75 mg Capsule
- What is Pregafast 75 mg Capsule? - An anticonvulsant for neurotic pain, shingles, seizures, and fibromyalgia
- How long do I need to use Pregafast 75 mg Capsule before I see improvement in my condition? - Till improvement is observed
- At what frequency do I need to use Pregafast 75 mg Capsule? - As prescribed by the doctor
- Should I use Pregafast 75 mg Capsule empty stomach, before food or after food? - After food in prescribed dosage
- What are the instructions for the storage and disposal of Pregafast 75 mg Capsule? - Keep in a cool dry place, out of reach of children and pets