Vorimart 200 mg (Tablet)

Unit Price: ৳ 110.00 (1 x 10: ৳ 1,100.00)
Strip Price: ৳ 1,100.00

Medicine Details

Category Details
Generic Voriconazole
Company Desh pharmaceuticals ltd

Category

  • Antifungal Medicine
  • Pharmaceuticals
  • Medication

Indications

  • Treatment of invasive aspergillosis
  • Treatment of candidemia (nonneutropenic)
  • Treatment of disseminated candidiasis in skin, abdomen, kidney, bladder wall, and wounds
  • Treatment of esophageal candidiasis
  • Treatment of serious infections caused by Scedosporium apiospermum and Fusarium Species
  • Treatment for patients intolerant of, or refractory to other therapy

Pharmacology

  • Binds and inhibits ergosterol synthesis
  • Inhibits CYP450-dependent 14-alpha sterol demethylase
  • Results in depletion of ergosterol in fungal cell membrane

Dosage & Administration

  • Oral administration with or without meals
  • Different dosage regimens for patients above and below 40 kg body weight
  • Loading dose regimen followed by maintenance dose
  • Injection dosage for invasive aspergillosis, candidemia, Scedosporiosis, and Fusariosis

Interaction

  • Adjust dosage and monitor for adverse reactions in the presence of CYP3A4, CYP2C9, and CYP2C19 inhibitors and inducers
  • Potential increase in concentrations and activity of drugs that are CYP3A4, CYP2C9, and CYP2C19 substrates
  • Increase maintenance dosage with co-administration of specific drugs

Contraindications

  • Known hypersensitivity to Voriconazole or any other components
  • Co-administration contraindications with specific drugs

Side Effects

  • Abdominal pain
  • Anemia
  • Blurred vision
  • Headache
  • Chest pain
  • Nausea
  • Diarrhea

Pregnancy & Lactation

  • Use during pregnancy if the potential benefit justifies the potential risk to the fetus

Precautions & Warnings

  • Careful assessment required for long term exposure greater than 180 days
  • Reported association with squamous cell carcinoma of the skin (SCC) with long-term treatment

Use in Special Populations

  • Efficacy not established in children under 12 years of age

Overdose Effects

  • No data available for overdose effects

Therapeutic Class

  • Other Antifungal preparations

Reconstitution

  • Instructions for reconstituting suspension
  • Shake the bottle well before adding water to loosen the powder
  • Specific water volume and storage instructions provided

Storage Conditions

  • Store in a dry place below 25°C temperature and protected from light
  • Special storage requirement for Vorimart powder for suspension

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