Lescol XL 80 mg (Capsule)

Indications

• Therapy with lipid-altering agents for atherosclerotic vascular disease
• Adjunct to diet for hypercholesterolemia

Pharmacology

• Competitive inhibition of HMG-CoA reductase
• Reduction in total cholesterol and triglycerides
• Increased HDL concentrations

Dosage & Administration

• Initial dose of 20-40 mg once daily, max 80 mg/day for adults
• 20 mg once daily for children, with potential dose increase

Interaction

• Potential interactions with coumarin anticoagulants, HIV protease inhibitors, colchicine, niacin, ciclosporin, and fluconazole
• Reduced bioavailability with rifampicin

Contraindications

• Acute liver disease
• Pregnancy and lactation
• Avoidance of administration of two 40 mg conventional caps simultaneously

Side Effects

• Headache
• Nausea
• Abdominal pain
• Bronchitis, sinusitis
• Fatigue
• Myopathy, myalgia
• Increased blood creatinine phosphokinase and transaminase

Pregnancy & Lactation

• Category X for use in pregnant women

Precautions & Warnings

• History of liver disease and hereditary muscular disorders
• Manage hypothyroidism prior to treatment
• Severe renal impairment

Use in Special Populations

• No dosage adjustment needed for mild to moderate renal impairment

Overdose Effects

• Symptomatic and supportive treatment

Therapeutic Class

• Other Anti-anginal & Anti-ischaemic drugs
• Statins

Storage Conditions

• Store between 15-30°C

Related Brands

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