Cardisan 100 mg (Tablet)

Indications

• Treatment of hypertension
• Delaying the progression of renal disease in hypertensive type-2 diabetics with proteinuria

Pharmacology

• Non-peptide orally active angiotensin II receptor blocker
• Binds to AT1 receptor in various tissues
• Reduces vasoconstriction and aldosterone release responsible for hypertension

Dosage & Administration

• Usual starting and maintenance dose of 50 mg once daily
• Can be used alone or in combination with other antihypertensive agents
• Total daily dose ranges from 25 mg to 100 mg
• Different starting dose for patients over 75 years and with intravascular volume-depletion

Interaction

• Reduction of active metabolite levels when used with rifampicin and fluconazole
• Potentiation of antihypertensive effects when used with hydrochlorothiazide
• Increased serum potassium when used with potassium-sparing diuretics or supplements
• Potential risk of renal impairment with concomitant use of certain drugs

Contraindications

• Contraindicated in pregnant women
• Contraindicated in patients hypersensitive to any component
• Not to be administered with Aliskiren in diabetic patients

Side Effects

• Mild and transient side effects
• Common side effects include dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection
• Other side effects include fatigue, edema, abdominal pain, chest pain, nausea, headache, and pharyngitis

Pregnancy & Lactation

• Pregnancy Category D
• Risk to fetus when administered during second or third trimesters
• Unknown excretion in human milk
• Decision should be made whether to discontinue nursing or discontinue the drug

Precautions & Warnings

• Reduction of fetal renal function and increase in fetal and neonatal morbidity and death during second and third trimesters
• Symptomatic hypotension in intravascularly volume-depleted patients
• Significantly increased plasma concentration in cirrhotic patients
• Changes in renal function including renal failure in renal impaired patients

Use in Special Populations

• No initial dosage adjustment necessary in patients with mild renal impairment
• Lower starting dose recommended for patients with moderate to severe renal impairment or on dialysis
• Lower dose recommended for patients with hepatic impairment
• Contraindicated in pregnancy and in patients hypersensitive to losartan

Therapeutic Class

• Angiotensin II receptor blocker

Storage Conditions

• Keep in a dry place away from light and heat
• Keep out of the reach of children

Related Brands

• Usapa 50 mg (Tablet) - union-pharmaceuticals-ltd
• Usapa 25 mg (Tablet) - union-pharmaceuticals-ltd