Xelmet XR 500 mg (Tablet (Extended Release))
Unit Price: ৳ 7.00 (4 x 7: ৳ 196.00)
Strip Price: ৳ 49.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of type 2 diabetes in overweight patients
- Monotherapy for adults
- Combination therapy for adults
- Monotherapy for children from 10 years of age and adolescents
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Improves insulin sensitivity
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Dosage increases in increments
- Different dosages for adults and children
- Immediate release tablet
- Extended release tablet
- Administration with meals
- Not exceeding maximum daily doses
- Dosage adjustment for renal impaired patient
Interaction
- No chronic co-administration information
- Enhancement of absorption by Nifedipine
- Competing with cationic drugs for renal tubular transport systems
- No effect on Cimetidine pharmacokinetics
- Potential drug-induced hyperglycemia
- Interaction with specific drugs
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Acute or chronic diseases causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality
- Recommendation of insulin use during pregnancy
- Excretion into human breast milk
- Limited data on breastfeeding
Precautions & Warnings
- Excreted by the kidney
- Risk of lactic acidosis increases with impaired renal function
- Lowering vitamin B12 level
- Increased risk of hypoglycemia in combination therapy
- Monitoring of renal function
- Therapy adjustments before surgery and clinical investigations
Use in Special Populations
- Dosage adjustment in elderly subjects
- Effect on growth and puberty in children
- Caution for children aged between 10 and 12 years
- Assessment of renal function before and during treatment
- Contraindicated in patients with GFR <30 ml/min
Overdose Effects
- No hypoglycemia seen at high doses
- Occurrence of lactic acidosis
- Emergency treatment in hospital
- Hemodialysis for removing lactate
Therapeutic Class
- Biguanides
Storage Conditions
- Temperature and light restrictions
- Protection from moisture
- Keep out of the reach of children