Aproxi 40 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Aprepitant |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Indications
- Prevention of postoperative nausea and vomiting (PONV)
- Prevention of Chemotherapy Induced Nausea and Vomiting (CINV)
Pharmacology
Aprepitant is a selective high affinity antagonist of human substance P neurokinin 1 (NK1) receptors, preventing nausea and vomiting.
Dosage
- Post Operative Nausea and Vomiting: 40 mg within 3 hours prior to induction of anesthesia
- Chemotherapy-Induced Nausea and Vomiting:
- Day 1: Aprepitant 125 mg orally, Dexamethasone 12 mg orally, 5-HT3 antagonist (Ondansetron): 24 mg 30 minutes before the start of chemotherapy
- Day 2: Aprepitant 80 mg orally, Dexamethasone 8 mg orally
- Day 3: Aprepitant 80 mg orally, Dexamethasone 8 mg orally
- Day 4: Dexamethasone 8 mg orally
Administration
Aprepitant may be taken with or without food. No dosage adjustment is necessary for elderly patients.
Interactions
Aproxi is a substrate, a weak-to-moderate (dose dependent) inhibitor, and an inducer of CYP3A4. Precautions should be taken while coadministering Aproxi with drugs that use CYP3A4 or CYP2C9.
Contraindications
Aprepitant is contraindicated in patients who are hypersensitive to any component of the product, and should not be used concurrently with specific drugs.
Side Effects
- Constipation
- Hypotension
- Pruritus
- Pyrexia
Pregnancy & Lactation
Pregnancy Category B. A decision should be made whether to discontinue nursing or to discontinue the drug based on patient’s importance.
Use in Special Populations
- Patients with Renal Impairment: No dosage adjustment is necessary for patients with renal impairment or those undergoing hemodialysis.
- Patients with Hepatic Impairment: No dosage adjustment is necessary for patients with mild to moderate hepatic impairment.
Overdose Effects
No specific information is available on the treatment of overdosage with Aproxi.
Therapeutic Class
Anti-emetic drugs
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.