Fenafex 30 mg/5 ml (Oral Suspension)

50 ml bottle: ৳ 50.00

Medicine Details

Category	Details
Generic	Fexofenadine hydrochloride
Company	Maks drug limited
Also available as	Fenafex 120 mg tablet

Relief of symptoms from allergic rhinitis in adults and children 12 years and older
Relief of symptoms from chronic idiopathic urticaria in adults and children 12 years and older

H1 histamine receptor mediated hypersensitivity and allergic reactions
Exposure to allergen results in degranulation of mast cells and basophils
Histamine binds to and activates H1 receptors, resulting in release of pro-inflammatory cytokines
Fexofenadine acts as an inverse agonist of the H1 receptor
Fexofenadine has potent and selective affinity for H1 receptors with no evidence of other activity
Fexofenadine does not cross the blood-brain barrier

Adults and children 12 years and older: 60 mg twice daily or 120 mg once daily or 180 mg once daily for allergic rhinitis
Children from 6 to 11 years: 30 mg twice daily or 60 mg once daily for allergic rhinitis
Children from 2 to 11 years: 30 mg or 5 ml twice daily, dosage adjustment for impaired renal function
Adults and children 12 years and older: 60 mg twice daily or 120 mg once daily or 180 mg once daily for chronic idiopathic urticaria
Children from 6 to 11 years: 30 mg twice daily or 60 mg once daily for chronic idiopathic urticaria
Children from 6 months to less than 2 years: 15 mg or 2.5 ml twice daily, dosage adjustment for impaired renal function

No hepatic biotransformation, no interaction with medicinal products through hepatic mechanisms
Coadministration with erythromycin or ketoconazole results in 2-3 times increase in fexofenadine level in plasma
No interaction with omeprazole observed
Antacid containing aluminium and magnesium hydroxide gels 15 minutes prior to administration causes reduction in bioavailability

Nervous system disorders: headache, drowsiness, dizziness
Gastrointestinal disorders: nausea, diarrhea
General disorders and administration site conditions: fatigue
Immune system disorders: hypersensitivity reactions with manifestations such as angioedema, chest tightness, dyspnoea, flushing and systemic anaphylaxis
Psychiatric disorders: insomnia, nervousness, sleep disorders or nightmares/excessive dreaming
Cardiac disorders: tachycardia, palpitations
Skin and subcutaneous tissue disorders: rash, urticaria, pruritus

No adequate data from use in pregnant women
Limited animal studies do not indicate direct or indirect harmful effects
Fexofenadine hydrochloride not recommended for mothers breast-feeding their babies
No human data on the effect of Fexofenadine hydrochloride on fertility

Limited data in older people and renally or hepatically impaired patients
Caution advised in these special groups
Patients with history of or ongoing cardiovascular disease warned of adverse reactions like tachycardia and palpitations
Unlikely to produce effect on ability to drive or use machines

Reported effects: dizziness, drowsiness, fatigue, dry mouth
No development of clinically significant adverse reactions reported with doses up to 800 mg
Recommended standard measures for removal of unabsorbed medicinal product