Novas E 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 14.00 (3 x 10: ৳ 420.00)
Strip Price: ৳ 140.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Maks drug limited

Indications

  • Relief of signs & symptoms of Osteoarthritis
  • Relief of signs & symptoms of Rheumatoid arthritis
  • Relief of signs & symptoms of Ankylosing spondylitis
  • Decrease risk of developing gastric ulcers in patients at risk of NSAID-associated gastric ulcers

Pharmacology

  • Consists of immediate release Esomeprazole Magnesium layer & enteric-coated Naproxen core
  • Naproxen is a NSAID with analgesic & antipyretic properties
  • Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by inhibition of the H+/k+ -ATPase in gastric parietal cells

Dosage

  • Use lowest effective dose for the shortest duration
  • Adult dosage: 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole twice daily
  • Adolescent dosage: 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole for weight greater than 50 kg

Administration

  • Do not split, chew, crush or dissolve the tablet
  • Take at least 30 minutes before meals

Interaction

  • Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
  • Concomitant use of tablet and warfarin may result in increased risk of bleeding complication
  • Esomeprazole may interfere with the absorption of drugs like Ketoconazole, iron salts and digoxin

Contraindications

  • Known hypersensitivity to any component of this tablet
  • History of asthma, urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
  • Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

  • Decrease occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events compared to Naproxen alone
  • May be associated with a small increased risk of arterial thrombotic events
  • Common adverse events are gastrointestinal in nature

Pregnancy & Lactation

  • Not recommended during the first and second trimester of pregnancy
  • Contraindicated during the third trimester of pregnancy
  • Excreted in low quantities in human milk, should not be used during breastfeeding

Precautions & Warnings

  • Avoid combination with other NSAIDs
  • Minimize undesirable effects by using lowest effective dose for shortest duration
  • Risk-factors for developing NSAID-related gastro-intestinal complications should be considered

Use in Special Populations

  • Use caution and possible dosage adjustment in elderly patients
  • Not recommended for use in patients with moderate to severe or severe renal impairment
  • Monitor and consider dose reduction in patients with hepatic insufficiency

Overdose Effects

  • Symptoms of overdose include lethargy, dizziness, drowsiness, epigastric pain, abdominal discomfort, heartburn, and more
  • Patients should be managed by symptomatic and supportive care following a NSAID overdose
  • No specific antidote known for Esomeprazole overdose

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store at temperature below 30°C
  • Protect from light & moisture
  • Keep out of reach of children

Related Brands