Leviceta 500 mg/5 ml (Oral Solution)

50 ml bottle: ৳ 180.00

Medicine Details

Category Details
Generic Levetiracetam
Company General pharmaceuticals ltd
Also available as
Leviceta 250 mg tablet Leviceta 500 mg tablet

Indications

  • Monotherapy in the treatment of partial-onset seizures
  • Adjunctive therapy for partial-onset seizures with or without secondary generalization
  • Treatment of myoclonic seizures in adolescents with Juvenile Myoclonic Epilepsy
  • Treatment of primary generalized tonic-clonic seizures in adults and adolescents with Idiopathic Generalised Epilepsy

Description

  • Mechanism of antiepileptic effect is unknown
  • Minimal activity in submaximal stimulation and in threshold tests
  • Inhibition of burst firing without affecting normal neuronal excitability

Dosage

  • Recommended starting dose for adults and adolescents
  • Initial therapeutic dose for adults and adolescents weighing 50 kg or more
  • Tablet formulation not adapted for use in infants and children under the age of 6 years
  • Safety and efficacy in children and adolescents below 16 years as monotherapy not established

Administration

  • Must be taken orally, swallowed with sufficient quantity of liquid
  • Daily dose administered in two equally divided doses

Interaction

  • No influence on serum concentrations of existing antiepileptic medicinal products
  • Inhibition of renal clearance of primary metabolite by Probenecid
  • Concomitant administration with methotrexate can decrease methotrexate clearance
  • Decreased efficacy when administered with osmotic laxative macrogol

Contraindications

  • Hypersensitivity to the active substance or other pyrrolidone derivatives or to any of the excipients

Side Effects

  • Most common adverse reactions include somnolence, asthenia, infection, and dizziness in adult patients
  • Fatigue, aggression, nasal congestion, decreased appetite, and irritability in pediatric patients

Pregnancy & Lactation

  • Not recommended during pregnancy and lactation
  • Excreted in human breast milk

Precautions & Warnings

  • Dose adjustment for patients with renal impairment
  • Rare cases of decreased blood cell counts
  • Monitoring for signs of depression and/or suicidal ideation and behaviours
  • Tablet formulation not adapted for use in infants and children under the age of 6 years

Use in Special Populations

  • Adjustment of the dose is recommended in elderly patients with compromised renal function
  • No dose adjustment needed in patients with mild to moderate hepatic impairment
  • 50% reduction of the daily maintenance dose recommended in severe hepatic impairment

Overdose Effects

  • Observed effects include somnolence, agitation, respiratory depression, and coma
  • No specific antidote available
  • Treatment of an overdose will be symptomatic and may include haemodialysis

Therapeutic Class

  • Adjunct anti-epileptic drugs

Storage Conditions

  • Store at a cool temperature (not exceeding 25°C) and dry place, protected from light

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