Taxodoc 80 mg/vial (IV Infusion)

80 mg vial: ৳ 12,000.00

Medicine Details

Category	Details
Generic	Docetaxel trihydrate
Company	Renata limited
Also available as	Taxodoc 20 mg injection

Indications

Breast Cancer (BC)
Non-small Cell Lung Cancer (NSCLC)
Castration-Resistant Prostate Cancer (CRPC)
Gastric Adenocarcinoma (GC)
Squamous Cell Carcinoma of the Head and Neck (SCCHN)

Pharmacology

Antineoplastic agent
Microtubular network disruptor
Mitotic and interphase cellular functions disruptor
Tubulin assembly promoter
Tubulin disassembly inhibitor
Cytotoxic effect on tumor cell lines
P-glycoprotein inhibitor

Dosage & Administration

Intravenous administration
Premedication with oral corticosteroids
Patient-specific dose adjustment
Administration in a facility equipped to manage complications

Interaction

CYP3A4 substrate
Metabolism modification potential by concomitant compounds

Contraindications

Neutrophil count <1500 cells/mm³
History of severe hypersensitivity reactions to docetaxel or polysorbate 80

Side Effects

Infections
Neutropenia
Anemia
Febrile neutropenia
Hypersensitivity
Thrombocytopenia
Neuropathy
Dysgeusia
Dyspnea
Constipation
Anorexia
Nail disorders
Fluid retention
Asthenia
Pain
Nausea
Diarrhea
Vomiting
Mucositis
Alopecia
Skin reactions
Myalgia

Pregnancy & Lactation

Potential fetal harm
Lack of information on presence in human milk
No lactation studies in animals

Precautions & Warnings

Supervised administration by experienced physician
Higher risk in patients with hepatic impairment
Neutrophil count threshold
Potential fatal hypersensitivity reactions
Treatment-related acute myeloid leukemia risk

Overdose Effects

Reports of overdosage
No known antidote
Expected complications: bone marrow suppression, peripheral neurotoxicity, mucositis
Close monitoring of vital functions

Therapeutic Class

Cytotoxic Chemotherapy

Storage Conditions

Temperature range 2°C to 25°C
Protected from light
Freezing does not adversely affect the product

Related Brands