Xorel 10 mg (Capsule (Enteric Coated))

Unit Price: ৳ 3.00 (10 x 10: ৳ 300.00)
Strip Price: ৳ 30.00

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Ibn sina pharmaceuticals ltd
Also available as
Xorel 20 mg tablet Xorel 20 mg capsule Xorel 10 mg tablet Xorel mups 20 mg tablet

Indications

  • Active duodenal ulcer
  • Active benign gastric ulcer
  • Symptomatic erosive or ulcerative gastro-esophageal reflux disease (GERD)
  • Gastro-esophageal Reflux Disease Long-term Management (GERD Maintenance)
  • Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • Zollinger-Ellison Syndrome
  • In combination with appropriate antibacterial therapeutic regimens for the eradication of Helicobacter pylori in patients with peptic ulcer disease

Pharmacology

  • Suppresses gastric acid secretion by inhibiting the gastric H+/K+-ATPase
  • Characterized as a gastric proton-pump inhibitor

Dosage

  • Recommended oral dose for active duodenal ulcer and active benign gastric ulcer is 20 mg once daily
  • Recommended oral dose for erosive or ulcerative gastro-esophageal reflux disease (GERD) is 20 mg once daily for four to eight weeks
  • For long-term management, a maintenance dose of rabeprazole sodium 20 mg or 10 mg once daily can be used
  • 10 mg once daily for symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • Initial adult dose for Zollinger-Ellison Syndrome is 60 mg once a day, may be titrated upwards to 120 mg/day

Administration

Tablets should be taken in the morning, before eating, and swallowed whole

Interaction

  • Potential interaction with compounds whose absorption is pH dependent
  • Co-administration with ketoconazole or itraconazole may result in a significant decrease in antifungal plasma levels
  • No interaction with liquid antacids observed

Contraindications

  • Hypersensitivity to the active substance or to any of the excipients
  • Contra-indicated in pregnancy and during breastfeeding

Side Effects

  • May cause headache, diarrhea, abdominal pain, vomiting, constipation, dry mouth, increased or decreased appetite, muscle pain, drowsiness, dizziness

Pregnancy & Lactation

US FDA pregnancy category 'C'. No adequate and well-controlled studies in pregnant women

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric or oesophageal malignancy
  • Patients on long-term treatment should be kept under regular surveillance
  • May increase the risk of hip, wrist and spine fracture, especially in the elderly
  • A risk of cross-hypersensitivity reactions with other proton pump inhibitor or substituted benzimidazoles cannot be excluded

Use in Special Populations

  • No dosage adjustment is necessary for patients with renal or hepatic impairment
  • Not recommended for use in children due to a lack of data on safety and efficacy

Overdose Effects

The maximum established exposure has not exceeded 60 mg twice daily, or 160 mg once daily; effects are generally minimal, representative of the known adverse event profile and reversible without further medical intervention; no specific antidote is known

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep below 30°C temperature, away from light & moisture; keep out of the reach of children

Chemical Structure

  • Molecular Formula: C18H21N3O3S
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-942-rabeprazole-sodium-chemical-structure-atwg0Q4PlndQZhOY9GHX.svg

Common Questions

  • Xorel 10 mg Capsule is a proton pump inhibitor (PPI) that suppresses gastric acid secretion
  • Used to treat duodenal ulcer, gastric ulcer, GERD, Zollinger-Ellison Syndrome, Helicobacter pylori eradication
  • Side effects include diarrhea, constipation, nausea, vomiting, headache, dizziness, rash, dry mouth; serious side effects are rare but can include kidney problems, liver damage, and bone fractures
  • Should be taken with food; usual dose is one tablet once a day
  • Not recommended for use during pregnancy or breastfeeding
  • If overdose occurs, call doctor or Poison Control Center immediately
  • Length of treatment depends on the condition being treated
  • Can cause thinning of bones with long-term use; recommended to take vitamin D as a supplement
  • Can cause dry mouth and constipation; drink plenty of fluids and eat a high-fiber diet to prevent constipation

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