Unargan 5 mg/5 ml (Oral Solution)
100 ml bottle: ৳ 15.44
Medicine Details
| Category | Details |
|---|---|
| Generic | Promethazine hydrochloride |
| Company | Union pharmaceuticals ltd |
Indications
- Symptomatic treatment of allergic conditions of the respiratory tract and skin
- Sensitization reactions to drug or foreign proteins
- Anaphylactic reactions
- Sedation
- Allergic rhinitis
- Urticaria
- Insomnia
- Pre-operative sedation in surgery and obstetrics
- Paediatric sedative
Pharmacology
- Phenothiazine derivative
- Blocks postsynaptic mesolimbic dopaminergic receptors
- Strong alpha-adrenergic blocking effect
- Depresses release of hypothalamic and hypophyseal hormones
- Competes with histamine for H1-receptor
- Muscarinic blocking effect
- Reduces stimuli to brainstem reticular system
- Well absorbed from gastrointestinal tract
- Clinical effects appear within 20 minutes after oral administration
- Metabolized by the liver
Dosage & Administration
- Initial dose for adults: one 25 mg tablet at night
- May be increased to two or three 25 mg tablets at night if necessary
- Elderly dosage not specified
- Children treatment with elixir containing 5 mg/5 ml
- Dosage for antihistamine and sedative for children
Interaction
- Enhances the action of anticholinergic agents
- May interfere with immunologic urine pregnancy tests
- Discontinuation required before skin tests using allergen extracts
Contraindications
- Contraindicated for children under two years
- Hypersensitivity to promethazine or excipients
- Should not be used in coma or CNS depression patients
- Avoid in neonates or premature infants
- Avoid in patients using MAO inhibitors within 14 days
Side Effects
- Neuroleptic Malignant Syndrome (NMS)
- Anticholinergic effects in the elderly
- Confusion
- Somnolence
- Dizziness
- Headaches
- Extrapyramidal effects
- Allergic reactions
- Photosensitivity reaction
- Anorexia
- Gastrointestinal discomfort
- Blurred vision
- Blood dyscrasias
- Urinary retention
- Psychiatric effects
- Cardiac disorders
- Hypotension
- Jaundice
- Tiredness
Pregnancy & Lactation
- Safety in pregnancy supported by epidemiological evidence
- Not recommended in the two weeks prior to delivery
- Risk of irritability and excitement in neonate
- Excreted in breastmilk
- Risks of neonatal irritability and excitement
Precautions & Warnings
- Avoid in children with signs suggestive of Reye's syndrome
- May thicken or dry lung secretions
- Use caution in patients with asthma, bronchitis, or bronchiectasis
- Care needed in patients with coronary artery disease
- Care needed in patients with narrow angle glaucoma
- Care needed in patients with epilepsy
- Care needed in patients with hepatic insufficiency
- Caution in patients with renal insufficiency
- Exercise caution in patients with bladder neck obstruction
- Exercise caution in patients with pyloro-duodenal obstruction
Overdose Effects
- Symptoms variable
- Excitation, ataxia, hallucinations in children
- Drowsiness, coma in adults
- Convulsions possible
- Cardiorespiratory depression uncommon
- Treatment involves inducing vomiting or gastric lavage
- Supportive treatment required
- Convulsions may be treated with diazepam
Therapeutic Class
- Anti-emetic drugs
- Miscellaneous sedatives & hypnotics
- Sedating antihistamine
Storage Conditions
- Protect from light
- Do not use after expiry date
- Keep out of reach of children
- Dispensed only on prescription