Umox 250 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Amoxicillin trihydrate |
| Company | Union pharmaceuticals ltd |
| Also available as |
Indications
- Ear, nose and throat infections
- Lower respiratory tract infections
- Skin and soft tissue infections
- Genito-urinary tract infections
- Venereal disease
- Dental abscess
Pharmacology
- Broad spectrum penicillin
- Effective against Gram-positive and Gram-negative bacteria
- Inhibition of cell wall biosynthesis
- Stable in the presence of gastric acid
- Rapidly absorbed after oral administration
- Widely distributed in body tissues and fluids
Dosage
- Adult: 250 mg three times daily, increasing up to 500 mg three times daily for severe infections
- Children: 125 mg three times daily, increasing up to 250 mg three times daily for severe infections
- Severe or recurrent purulent respiratory infection: 3 gm every 12 hours
- Otitis media: Recommended dose is 1 g three times daily for adult and 40 mg/kg body weight daily in 3 divided doses for children (max. 3 g daily)
- Pneumonia: Recommended dose is 500-1000 mg three times daily
- Dental abscess: Recommended dose is 3 gm, repeated after 10-12 hours
- Urinary tract infections: Recommended dose is 3 gm, repeated after 10-12 hours
- Gonorrhoea: Single dose of 2-3 gm with Probenecid 1 gm is recommended (Probenecid is contraindicated in children under 2 years)
- In renal impairment: It may be necessary to reduce the total daily dosage
Administration
Reconstituted suspension can be administered by adding the required amount of suspension to milk, fruit juice, water. These preparations should then be taken immediately
Interaction
Concurrent use of Umox and Probenecid may result in increased and prolonged blood levels of Umox. Umox may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives
Contraindications
Amoxicillin is contraindicated in penicillin hypersensitive patients
Side Effects
- Diarrhoea
- Indigestion
- Rash
- Pseudo-membranous colitis (rare)
Pregnancy & Lactation
US FDA pregnancy category of Amoxicillin is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Amoxicillin has been shown to be excreted in human milk. So, caution should be exercised when Amoxicillin is administered to a lactating mother
Precautions & Warnings
The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur, Umox should be discontinued and appropriate therapy should be instituted
Therapeutic Class
Broad spectrum penicillins
Reconstitution
- Intramuscular: Add 2.5 ml water for injection to Amoxycillin 500 mg injection vial
- Intravenous: Dissolve Amoxycillin 500 mg injection in 10 ml water for injection
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children