U-Pepton 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 4.00 (5 x 10: ৳ 200.00)
Strip Price: ৳ 40.00

Medicine Details

Category Details
Generic Pantoprazole sodium
Company Union pharmaceuticals ltd

Indications

  • Peptic ulcer diseases
  • Gastroesophageal reflux diseases
  • Ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs)
  • Eradication of Helicobacter pylori (in combination with antibiotics)
  • Zollinger-Ellison Syndrome

Pharmacology

Pantoprazole is a proton pump inhibitor that suppresses the final step in gastric acid production by covalently binding to the H+/K+ATPase enzyme system at the surface of the gastric parietal cell.

Dosage & Administration

  • Benign gastric ulcer: 40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed
  • Gastro-esophageal reflux disease: 20-40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed; maintenance dose is 20 mg daily, which may be increased to 40 mg daily
  • Duodenal ulcer: 40 mg daily in the morning for 2 weeks, continued for further 2 weeks if not fully healed
  • Duodenal ulcer associated with Helicobacter pylori: Pantoprazole is recommended at a dose of 40 mg twice daily in association with antimicrobial agents
  • Prophylaxis of NSAID-associated gastric or duodenal ulcer: 20 mg daily for those require long-term NSAID treatment
  • Zollinger-Ellison Syndrome: Initially 80 mg once daily adjusted according to response (elderly max. 40 mg daily); daily doses above 80 mg given in 2 divided doses
  • Duodenal ulcer and gastric ulcer: 40 mg once daily for 7-10 days (IV Injection)
  • Gastroesophageal reflux disease associated with a history of erosive esophagitis: 40 mg once daily for 7-10 days (IV Injection)
  • Prevention of rebleeding in peptic ulcer: IV 80 mg, followed by 8 mg/hour infusion for 72 hours (IV Injection)
  • Prophylaxis of acid aspiration: 80 mg IV every 12 h for 24 h, followed by 40mg every 12 hour (IV Injection)
  • Long-term management of Zollinger-Ellison Syndrome and other pathological hypersecretory conditions: 80 mg IV every 12 hours, may increase to 80 mg every 8 hours if needed, may titrate to higher doses depending on acid output

Interaction

No significant drug interactions have been observed in clinical studies.

Contraindications

Pantoprazole is contraindicated in patients with known hypersensitivity to any of the components of the formulation.

Side Effects

  • Headache
  • Diarrhea
  • Abdominal pain
  • Flatulence
  • Rash
  • Insomnia
  • Hyperglycemia

Pregnancy & Lactation

US FDA Pregnancy Category of Pantoprazole is B. It should be used during pregnancy only if clearly needed. Pantoprazole has been shown to be excreted in human milk.

Precautions & Warnings

Patients should be cautioned that U-Pepton tablet should not be split, chewed or crushed. Long-term therapy of U-Pepton may lead to malabsorption of cyanocobalamin (Vitamin B12) or may increase the risk of osteoporosis related disorders.

Overdose Effects

There are no known symptoms of overdosage in humans. No specific therapy is recommended.

Therapeutic Class

Proton Pump Inhibitor

Reconstitution

U-Pepton IV injection should be given as a slow intravenous injection. The solution for IV injection is obtained by reconstitution with 0.9% Sodium Chloride Injection.

Storage Conditions

Keep in a dry place, away from light and heat. Keep out of the reach of children.

Chemical Structure

  • Molecular Formula: C16H15F2N3O4S

Common Questions

  • What is U-Pepton 20 mg Tablet?
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  • What are the instructions for the storage and disposal of U-Pepton 20 mg Tablet?
  • What are the effects of U-Pepton 20 mg Tablet on older adults?
  • How long does it take for U-Pepton 20 mg Tablet to work?
  • Is U-Pepton 20 mg Tablet safe?
  • Does U-Pepton 20 mg Tablet cause weight gain?
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  • Can I take U-Pepton 20 mg Tablet if I am pregnant or breastfeeding?
  • What should I do if I miss a dose of U-Pepton 20 mg Tablet?

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