Usapa 50 mg (Tablet)

Unit Price: ৳ 6.00 (3 x 10: ৳ 180.00)

Strip Price: ৳ 60.00

Medicine Details

Usual starting and maintenance dose of 50 mg once daily
25 mg twice daily if 50 mg once daily is inadequate
Starting dose of 25 mg once daily for patients with intravascular volume-depletion
Lower starting dose of 25 mg once daily recommended for patients over 75 years

Reduction in levels of active metabolite of Usapa by rifampicin and fluconazole
Potentiation of antihypertensive effects with concomitant use of Usapa and hydrochlorothiazide
Increase in serum potassium with concomitant use of potassium-sparing diuretics, potassium supplements or salt substitutes
Attenuation of antihypertensive effect by non-steroidal anti-inflammatory drug indomethacin
Increased risk of renal impairment with concomitant use of ACE-inhibitor, angiotensin receptor antagonist, anti-inflammatory drug, and thiazide diuretic

Mild and transient side effects
Common side effects: dizziness, diarrhea, nasal congestion, cough, upper respiratory infection
Other side effects: fatigue, oedema, abdominal pain, chest pain, nausea, headache, pharyngitis

Pregnancy Category D
Risk increases if administered during the second or third trimesters
Unknown excretion in human milk, potential for adverse effects on nursing infant

Reduction of fetal renal function and increase in fetal and neonatal morbidity and death with use during the second and third trimesters of pregnancy
Symptomatic hypotension may occur in patients intravascularly volume-depleted
Significantly increased plasma concentration in cirrhotic patients
Changes in renal function including renal failure reported in patients with renal impairment

No initial dosage adjustment necessary in patients with mild renal impairment
Lower starting dose recommended for patients with moderate to severe renal impairment or on dialysis
Lower dose should be considered for patients with a history of hepatic impairment
Usapa should not be used with potassium-sparing diuretics