Uzin 10 mg (Tablet)

Indications

• Relief of symptoms associated with seasonal allergic rhinitis
• Relief of symptoms associated with perennial allergic rhinitis
• Treatment of uncomplicated skin manifestations of chronic idiopathic urticaria
• Treatment of allergen induced asthma

Pharmacology

• Potent H1 receptor antagonist
• No significant anticholinergic effects
• No significant antiserotonic effects
• Inhibits histamine-mediated early phase of allergic reaction
• Reduces migration of inflammatory cells
• Reduces release of mediators associated with late phase of allergic reaction
• Achieves peak plasma concentrations of 257 mcg/L within one hour of administration
• Peak blood levels reached between thirty and sixty minutes after administration of 10 mg dose
• Plasma half-life approximately 11 hours
• Consistent absorption from one subject to the next
• Renal clearance is 30 ml/minute
• Excretion half-life approximately nine hours
• Food does not affect extent of absorption
• Food may slightly reduce the rate of absorption

Dosage & Administration

• Adult dosage: 1 tablet or 2 teaspoonfuls daily
• Children 6 years and older dosage: 1 tablet or 2 teaspoonfuls daily
• Children 2-6 years dosage: 1 teaspoonful once daily or 1/2 teaspoonful twice daily
• Children 6 months to 2 years dosage: 1/2 teaspoonful once daily
• Children 12-23 months dosage: Maximum dose of 1/2 teaspoonful every 12 hours
• Recommended injectable dosage for adults and adolescents: 10 mg administered by intravenous injection
• Recommended injectable dosage for children 6 to 11 years: 5 mg or 10 mg depending on symptom severity administered by intravenous injection
• Recommended injectable dosage for children 6 months to 5 years: 2.5 mg administered by intravenous injection
• Cetirizine injectable dosage form is for intravenous administration only

Interaction

• No clinically significant drug interactions with Theophylline
• No clinically significant drug interactions with Azithromycin
• No clinically significant drug interactions with Pseudoephedrine
• No clinically significant drug interactions with Ketoconazole
• No clinically significant drug interactions with Erythromycin
• No significant drug interactions with other drugs

Contraindications

• Contraindicated in patients with hypersensitivity to Cetirizine
• Contraindicated in patients with hypersensitivity to hydroxyzine

Side Effects

• Most common side effect: somnolence

Pregnancy & Lactation

• US FDA Pregnancy Category: B
• No adequate and well-controlled studies in pregnant women
• Drug excreted in human milk
• Caution should be exercised when administered to a nursing woman

Precautions & Warnings

• Caution should be exercised when driving a car
• Caution should be exercised when operating heavy machinery

Use in Special Populations

• Total body clearance reduced in patients with mild to moderate hepatic and renal impairment
• AUC and half-life increased by about 2 to 3 fold in patients with hepatic and renal impairment
• Plasma levels unaffected by hemodialysis
• Safety demonstrated in pediatric patients aged 6 months to 5 years
• Clearance reduced in elderly patients, proportionate to decrease in creatinine clearance

Therapeutic Class

• Sedating Anti-histamine

Storage Conditions

• Keep in a dry place away from light
• Keep in a dry place away from heat
• Keep out of the reach of children

Related Brands

• Cetrimak 10 mg (Tablet) - maks-drug-limited
• Cetirizine 10 mg (Tablet) - pristine-pharmaceuticals-ltd
• Libergy 10 mg (Tablet) - c2c-pharma-ltd