ZOM 500 mg (Tablet)

Unit Price: ৳ 30.00 (1 x 3: ৳ 90.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Azithromycin dihydrate
Company Union pharmaceuticals ltd

Title

  • ZOM 500 mg Tablet

Categories

  • Medicine
  • Pharmaceutical
  • Healthcare

Description

  • ZOM is indicated for infections (caused by susceptible organisms) in lower respiratory tract infections including bronchitis and pneumonia, in upper respiratory tract infections including sinusitis and pharyngitis/tonsillitis, in otitis media, and in skin and soft tissue infections. In sexually transmitted diseases in men and women, ZOM is indicated in the treatment of non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis.
  • Azithromycin is acid-stable and can therefore be taken orally with no need of protection from gastric acids. It is readily absorbed; its absorption is greater on an empty stomach. Time to peak concentration in adults is 2.1 to 3.2 hours for oral dosage forms. Due to the high concentration in phagocytes, azithromycin is actively transported to the site of infection. During active phagocytosis, large concentrations of azithromycin are released. The concentration of azithromycin in the tissues can be over 50 times higher than in plasma. This is due to ion trapping and the high lipid solubility.
  • Azithromycin's half-life allows a large single dose to be administered and yet maintain bacteriostatic levels in the infected tissue for several days. Following a single 500 mg dose, plasma concentrations of azithromycin declined in a polyphasic pattern with a mean apparent plasma clearance of 630 mL/min and a terminal elimination half-life of 68 hours. The prolonged terminal half-life is thought to be due to extensive uptake and subsequent release of drug from tissues. Biliary excretion of azithromycin, predominantly unchanged, is a major route of elimination. Over the course of a week, approximately 6% of the administered dose appears as unchanged drug in urine.
  • Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms and, thus, interfering with microbial protein synthesis. Nucleic acid synthesis is not affected. Azithromycin has been shown to be active against most isolates of various microorganisms.
  • Oral Adult: 500 mg once daily orally for 3 days or 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days. For sexually transmitted diseases caused by Chlamydia trachomatis in adults, the dose is 1 gm given as a single dose or 500 mg once on day 1, followed by 250 mg once daily for next 2 days may also be given.
  • Children: Different dosages based on body weight. Azithromycin Injection (For IV Infusion only) also has recommended dosage for different conditions.
  • Reconstitution procedure of suspension includes adding boiled and cooled water up to the water mark of the bottle label, and shaking until powder is completely mixed with water. Azithromycin should be taken at least 1 hour before or 2 hours after meal.
  • Interaction with antacids, carbamazepine, cyclosporin, digoxin, ergot derivatives, methylprednisolone, theophylline, warfarin, and terfenadine.
  • Azithromycin is contraindicated in patients hypersensitive to Azithromycin or any other macrolide antibiotic, co-administration of ergot derivatives and Azithromycin is contraindicated, and in patients with hepatic diseases.
  • Side effects include gastrointestinal issues, allergic reactions, reversible elevations in liver transaminases, cholestatic jaundice, mild reductions in neutrophil counts, and reversible hearing impairment in some patients.
  • Pregnancy Category of Azithromycin is B. Caution should be exercised when using Azithromycin during pregnancy and when administered to nursing women.
  • Rare serious allergic reactions, including angioneurotic oedema and anaphylaxis, have been reported. Caution should be exercised in special populations such as renal impairment, hepatic impairment, and individuals driving or operating machinery.
  • No data on overdosage with ZOM. Typical symptoms of overdosage with macrolide antibiotics include hearing loss, severe nausea, vomiting, and diarrhoea.
  • Storage conditions include keeping in a dry place away from light and heat, and out of the reach of children.

Attributes

  • Indications:
    • Lower respiratory tract infections
    • Upper respiratory tract infections
    • Otitis media
    • Skin and soft tissue infections
    • Sexually transmitted diseases
    • Bronchitis
    • Pneumonia
    • Sinusitis
    • Pharyngitis/tonsillitis
    • Non-gonococcal urethritis
    • Cervicitis
  • Mode of Action:
    • Oral absorption
    • Peak concentration time
    • High concentration in phagocytes
    • Ion trapping
    • High lipid solubility
    • Bacterial protein synthesis inhibition
  • Dosage:
    • Oral dosage for adults
    • Oral dosage for children
    • Azithromycin Injection dosage
  • Administration:
    • Reconstitution procedure for suspension
    • Meal timing for consumption
  • Interaction:
    • Antacid interaction
    • Carbamazepine interaction
    • Cyclosporin interaction
    • Digoxin interaction
    • Ergot derivatives interaction
    • Methylprednisolone interaction
    • Theophylline interaction
    • Warfarin interaction
    • Terfenadine interaction
  • Contraindications:
    • Hypersensitivity to Azithromycin or macrolide antibiotics
    • Co-administration with ergot derivatives
    • Hepatic diseases
  • Side Effects:
    • Gastrointestinal issues
    • Allergic reactions
    • Elevations in liver transaminases
    • Cholestatic jaundice
    • Neutrophil count reductions
    • Reversible hearing impairment
  • Pregnancy & Lactation:
    • Pregnancy Category B
    • No evidence of harm to the fetus
    • Caution in nursing women
  • Precautions & Warnings:
    • Rare serious allergic reactions
    • Special population considerations
  • Use in Special Populations:
    • Renal impairment
    • Hepatic impairment
    • Effects on driving and machinery operation
  • Overdose Effects:
    • Symptoms of overdosage
    • General overdose measures
  • Storage Conditions:
    • Dry place
    • Away from light and heat
    • Out of the reach of children
  • Chemical Structure:
    • Molecular Formula
    • Chemical Structure Image
  • Common Questions:
    • What is ZOM 500 mg Tablet?
    • Uses of ZOM 500 mg Tablet
    • Side Effects of ZOM 500 mg Tablet
    • Storage and disposal instructions for ZOM 500 mg Tablet
    • Diarrhea as a side effect
    • Safety of ZOM 500 mg Tablet
    • ZOM 500 mg Tablet as an antibiotic
    • Lack of improvement after taking ZOM 500 mg Tablet
    • Quick Tips for using ZOM 500 mg Tablet

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