Neoral 100 mg (Capsule)
Unit Price: ৳ 234.00 (10 x 5: ৳ 11,700.00)
Strip Price: ৳ 1,170.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cyclosporine oral |
| Company | Novartis bangladesh ltd |
| Also available as |
Indications
- Transplantation indications - Solid organ transplantation
- Transplantation indications - Bone marrow transplantation
- Non-transplantation indications - Endogenous uveitis
- Non-transplantation indications - Nephrotic syndrome
- Non-transplantation indications - Rheumatoid arthritis
- Non-transplantation indications - Psoriasis
- Non-transplantation indications - Atopic dermatitis
Pharmacology
- Cyclic polypeptide consisting of 11 amino acids
- Potent immunosuppressive agent
- Prolongs survival of allogeneic transplants
- Acts specifically and reversibly on lymphocytes
- Does not depress haemopoiesis
- No effect on the function of phagocytic cells
Dosage & Administration
- Solid organ transplantation: Initial dose: 10 to 15 mg/kg
- Bone marrow transplantation: Initial dose: 12.5 to 15 mg/kg
- Endogenous uveitis: Initial dose: 5 mg/kg per day
- Nephrotic syndrome: Initial dose: 5 mg/kg for adults, 6 mg/kg for children
- Rheumatoid arthritis: Recommended dose: 3 mg/kg per day for first 6 weeks
- Psoriasis & Atopic dermatitis: Initial dose: 2.5 mg/kg per day
Interaction
- Drugs that decrease Neoral levels: Barbiturates, carbamazepine, oxcarbazepine, phenytoin, etc.
- Drugs that increase Neoral levels: Macrolide antibiotics, ketoconazole, fluconazole, etc.
- Other relevant drug interactions: Neoral may reduce the clearance of digoxin, colchicine, prednisolone, etc.
Contraindications
- Hypersensitivity to ciclosporin or to any of the excipients of Sandimmun Neoral
- Kidney failure (except in patients with nephrotic syndrome)
- Uncontrolled hypertension
- Uncontrolled infection
- History of known or diagnosed malignancy
Side Effects
- Renal dysfunction
- Hypertension
- Tremor
- Gastrointestinal discomfort
- Hyperlipidemia
- Muscle cramps
- Skin reactions
Pregnancy & Lactation
Not recommended during pregnancy or breastfeeding
Precautions & Warnings
- Increases risk of developing lymphomas and other malignancies
- Avoid excess ultraviolet light exposure
- May develop bacterial, fungal, parasitic and viral infections
- Reversible increase in serum creatinine and urea
- Regular monitoring of blood pressure required
- Enhances risk of hyperkalaemia
- Vaccination may be less effective
Overdose Effects
Renal dysfunction, which resolves following drug withdrawal
Therapeutic Class
Immunosuppressant, Vaccines, Anti-sera & Immunoglobulin
Storage Conditions
Sporium oral solution should be used within 2 months of opening