Glifo-M 12.5 mg+500 mg (Tablet)
Unit Price: ৳ 30.00 (3 x 10: ৳ 900.00)
Strip Price: ৳ 300.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin metformin hydrochloride |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Adjunct to diet and exercise for type 2 diabetes mellitus
- Treatment for patients insufficiently controlled on Metformin alone
- Combination therapy for patients insufficiently controlled with Metformin and other medicinal products
- For patients already being treated with the combination of Empagliflozin and Metformin as separate tablets
Pharmacology
- Inhibition of Sodium-Glucose Co-Transporter 2 (SGLT2)
- Reduction of renal glucose reabsorption
- Lowering of renal threshold for glucose
- Decrease in hepatic glucose production
- Increase in peripheral glucose uptake and utilization
Dosage & Administration
- Individualized dosage based on effectiveness and tolerability
- Twice daily administration with meals
- Gradual dose escalation to reduce gastrointestinal side effects
- Maximum recommended daily doses for Metformin Hydrochloride and Empagliflozin
- Special dosing for renal impaired patients
- Extended-release formulations
- Pediatric patient dosage considerations
Interaction
- Effect of co-administration with diuretics
- Increased risk of hypoglycemia with insulin
- Monitoring glycemic control with urine glucose tests
- Drugs that reduce Metformin clearance
- Risk of lactic acidosis with carbonic anhydrase inhibitors
- Effect on glycemic control with various drug classes
- Potential interaction with alcohol
Contraindications
- Hypersensitivity to Empagliflozin and Metformin
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Diseases causing tissue hypoxia
- Hepatic impairment
- Acute alcohol intoxication
- Pregnancy and lactation
Side Effects
- Common adverse reactions
- Important adverse reactions for Empagliflozin and Metformin individually
- Occurrence of hypoglycemia and gastrointestinal symptoms
- Genital and urinary tract infections
- Thirst, taste disturbance, and rash
- Uncommon and rare adverse reactions
Pregnancy & Lactation
- Potential risk to fetus during second and third trimesters
- Not recommended during breastfeeding
Precautions & Warnings
- Lactic acidosis risk and management
- Hypotension assessment and monitoring
- Ketoacidosis evaluation and treatment
- Acute kidney injury considerations
- Risks of urinary tract infections and genital mycotic infections
- Hypoglycemia, Vitamin B12 deficiency, and LDL-C monitoring
- Lack of conclusive evidence for macrovascular risk reduction
Overdose Effects
- Absence of Empagliflozin toxicity in controlled studies
- Lack of hypoglycemia with Metformin doses
- Occurrence of lactic acidosis in extreme Metformin overdose
- Treatment methods for lactic acidosis
- No studied methods for Empagliflozin removal
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Storage temperature and protection instructions
- Safety measures for children