Glifo-M 12.5 mg+500 mg (Tablet)

Unit Price: ৳ 30.00 (3 x 10: ৳ 900.00)

Strip Price: ৳ 300.00

Medicine Details

Category	Details
Generic	Empagliflozin metformin hydrochloride
Company	Acme laboratories ltd
Also available as	Glifo m 5 mg tablet Glifo m xr 10 mg tablet Glifo m xr 25 mg tablet Glifo m xr 5 mg tablet

Indications

Adjunct to diet and exercise for type 2 diabetes mellitus
Treatment for patients insufficiently controlled on Metformin alone
Combination therapy for patients insufficiently controlled with Metformin and other medicinal products
For patients already being treated with the combination of Empagliflozin and Metformin as separate tablets

Pharmacology

Inhibition of Sodium-Glucose Co-Transporter 2 (SGLT2)
Reduction of renal glucose reabsorption
Lowering of renal threshold for glucose
Decrease in hepatic glucose production
Increase in peripheral glucose uptake and utilization

Dosage & Administration

Individualized dosage based on effectiveness and tolerability
Twice daily administration with meals
Gradual dose escalation to reduce gastrointestinal side effects
Maximum recommended daily doses for Metformin Hydrochloride and Empagliflozin
Special dosing for renal impaired patients
Extended-release formulations
Pediatric patient dosage considerations

Interaction

Effect of co-administration with diuretics
Increased risk of hypoglycemia with insulin
Monitoring glycemic control with urine glucose tests
Drugs that reduce Metformin clearance
Risk of lactic acidosis with carbonic anhydrase inhibitors
Effect on glycemic control with various drug classes
Potential interaction with alcohol

Contraindications

Hypersensitivity to Empagliflozin and Metformin
Acute metabolic acidosis
Severe renal failure
Conditions altering renal function
Diseases causing tissue hypoxia
Hepatic impairment
Acute alcohol intoxication
Pregnancy and lactation

Side Effects

Common adverse reactions
Important adverse reactions for Empagliflozin and Metformin individually
Occurrence of hypoglycemia and gastrointestinal symptoms
Genital and urinary tract infections
Thirst, taste disturbance, and rash
Uncommon and rare adverse reactions

Pregnancy & Lactation

Potential risk to fetus during second and third trimesters
Not recommended during breastfeeding

Precautions & Warnings

Lactic acidosis risk and management
Hypotension assessment and monitoring
Ketoacidosis evaluation and treatment
Acute kidney injury considerations
Risks of urinary tract infections and genital mycotic infections
Hypoglycemia, Vitamin B12 deficiency, and LDL-C monitoring
Lack of conclusive evidence for macrovascular risk reduction

Overdose Effects

Absence of Empagliflozin toxicity in controlled studies
Lack of hypoglycemia with Metformin doses
Occurrence of lactic acidosis in extreme Metformin overdose
Treatment methods for lactic acidosis
No studied methods for Empagliflozin removal

Therapeutic Class

Combination Oral hypoglycemic preparations

Storage Conditions

Storage temperature and protection instructions
Safety measures for children

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